Version 1
: Received: 28 March 2020 / Approved: 29 March 2020 / Online: 29 March 2020 (11:20:10 CEST)
How to cite:
Romanelli, A.; Mascolo, S. Crucial Aspects of the Management of Solid Organ Transplant Patient with COVID-19: A Narrative Review. Preprints2020, 2020030434. https://doi.org/10.20944/preprints202003.0434.v1
Romanelli, A.; Mascolo, S. Crucial Aspects of the Management of Solid Organ Transplant Patient with COVID-19: A Narrative Review. Preprints 2020, 2020030434. https://doi.org/10.20944/preprints202003.0434.v1
Romanelli, A.; Mascolo, S. Crucial Aspects of the Management of Solid Organ Transplant Patient with COVID-19: A Narrative Review. Preprints2020, 2020030434. https://doi.org/10.20944/preprints202003.0434.v1
APA Style
Romanelli, A., & Mascolo, S. (2020). Crucial Aspects of the Management of Solid Organ Transplant Patient with COVID-19: A Narrative Review. Preprints. https://doi.org/10.20944/preprints202003.0434.v1
Chicago/Turabian Style
Romanelli, A. and Silvia Mascolo. 2020 "Crucial Aspects of the Management of Solid Organ Transplant Patient with COVID-19: A Narrative Review" Preprints. https://doi.org/10.20944/preprints202003.0434.v1
Abstract
Many centers worldwide raised the concern that immunocompromised patients for solid organ transplantation may be at high risk of developing a severe respiratory disease by COVID-19. Currently, there are no specific data on the COVID-19 in patients with generalized immunosuppression and transplantation.In this narrative review, we reported the main data of COVID-19 in patients with solid organ transplantation presented in the literature. The aim is to elaborate a strategy for tailored management, from diagnosis to therapy.The management of adult patients with solid organ transplantation and COVID-19 is a challenge for the clinicians. There is a lack of data in the literature, but three key-points are crucial: in the “pandemic era,” consider the symptomatic patient as positive for COVID-19 until proven otherwise; adjust/stop immunosuppressive agents; protect graft function with adequate route and dose administration of glucocorticoid and supportive measures. For pediatric patients, data are scarce. It is unclear if immunosuppression in patients with solid organ transplantation alters the predisposition to acquiring COVID-19 or if the disease implications are modified for better or for worse. Further studies are needed.
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
