Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

ATP-Hypothesis: A New Conceptual Framework for the Origins of Genetic Codes

Version 1 : Received: 28 March 2020 / Approved: 29 March 2020 / Online: 29 March 2020 (04:08:22 CEST)
Version 2 : Received: 1 April 2020 / Approved: 2 April 2020 / Online: 2 April 2020 (05:16:09 CEST)
Version 3 : Received: 17 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (04:00:24 CEST)
Version 4 : Received: 11 July 2020 / Approved: 12 July 2020 / Online: 12 July 2020 (14:28:35 CEST)
Version 5 : Received: 26 July 2020 / Approved: 26 July 2020 / Online: 26 July 2020 (17:40:23 CEST)
Version 6 : Received: 6 August 2020 / Approved: 7 August 2020 / Online: 7 August 2020 (06:53:34 CEST)
Version 7 : Received: 16 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (08:54:53 CEST)
Version 8 : Received: 30 August 2020 / Approved: 31 August 2020 / Online: 31 August 2020 (08:05:13 CEST)
Version 9 : Received: 9 September 2020 / Approved: 11 September 2020 / Online: 11 September 2020 (08:39:39 CEST)

How to cite: Xie, P. ATP-Hypothesis: A New Conceptual Framework for the Origins of Genetic Codes. Preprints 2020, 2020030419 (doi: 10.20944/preprints202003.0419.v1). Xie, P. ATP-Hypothesis: A New Conceptual Framework for the Origins of Genetic Codes. Preprints 2020, 2020030419 (doi: 10.20944/preprints202003.0419.v1).

Abstract

The origin of genetic codes is the key to reveal life’s origin on the earth as it is a prerequisite for the existence of life. More than half a century has passed since the discovery of genetic codes, while their origin is still one of the greatest mysteries. Are the origins of genetic codes really unknowable? Do they really require external design? Here, we present an ATP-hypothesis that explains how the genetic codes came into being with the coevolution of biochemical system. ATP has several properties that make it suitable as the initiator of the origin of genetic codes. First, ATP is the only energetic product of photosynthesis. Second, ATP is at the heart of the extant biochemical systems. Third, ATP serves as carriers of both energy and information. Fourth, ATP could energetically elongate chains of both polynucleotides and polypeptides, thus providing a bridge between them, and eventually mediating prebiotic transaction from energy to information. This hypothesis shows how primitive life emerged through a series of processes from energy to information. Informatization (processes of creating and managing information) was inevitably coupled with structuralization (processes of organizing or incorporating into a cellular structure), making polynucleotides and polypeptides be cyclized into a system of reciprocal causation. The triplet codon might just be for stereo-chemical handing of amino acid through e.g. Watson–Crick pairing interactions. This hypothesis shades lights on the origin of life, together with the formations of both photosynthesis and biochemical systems, which have been largely unknown so far.

Subject Areas

origin of genetic codes; ATP-hypothesis; solar energy driven synthesis of chemicals; informatization; structuralization

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