Version 1
: Received: 26 March 2020 / Approved: 27 March 2020 / Online: 27 March 2020 (11:37:06 CET)
Version 2
: Received: 9 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (09:59:37 CEST)
How to cite:
Park, Y.; Ahn, J.W.; Hwang, S.; Sung, K.S.; Lim, J.; Kwack, K. Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses. Preprints2020, 2020030409 (doi: 10.20944/preprints202003.0409.v1).
Park, Y.; Ahn, J.W.; Hwang, S.; Sung, K.S.; Lim, J.; Kwack, K. Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses. Preprints 2020, 2020030409 (doi: 10.20944/preprints202003.0409.v1).
Cite as:
Park, Y.; Ahn, J.W.; Hwang, S.; Sung, K.S.; Lim, J.; Kwack, K. Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses. Preprints2020, 2020030409 (doi: 10.20944/preprints202003.0409.v1).
Park, Y.; Ahn, J.W.; Hwang, S.; Sung, K.S.; Lim, J.; Kwack, K. Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses. Preprints 2020, 2020030409 (doi: 10.20944/preprints202003.0409.v1).
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has high infectivity in humans, attributed to the strong affinity of its spike (S) protein to angiotensin-converting enzyme 2. Here, we analysed the structural similarity of the S protein between SARS-CoV-2 and other SARS-related coronaviruses. The S1 domain of the unclassified coronavirus RaTG13 was structurally very similar to that of SARS-CoV-2, implying that RaTG13 could be the origin of SARS-CoV-2.
Subject Areas
angiotensin-converting enzyme 2; SARS-CoV-2; spike protein
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
YoungJoon Park