Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses

Version 1 : Received: 26 March 2020 / Approved: 27 March 2020 / Online: 27 March 2020 (11:37:06 CET)
Version 2 : Received: 9 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (09:59:37 CEST)

How to cite: Park, Y.; Ahn, J.W.; Hwang, S.; Sung, K.S.; Lim, J.; Kwack, K. Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses. Preprints 2020, 2020030409 (doi: 10.20944/preprints202003.0409.v1). Park, Y.; Ahn, J.W.; Hwang, S.; Sung, K.S.; Lim, J.; Kwack, K. Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses. Preprints 2020, 2020030409 (doi: 10.20944/preprints202003.0409.v1).

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has high infectivity in humans, attributed to the strong affinity of its spike (S) protein to angiotensin-converting enzyme 2. Here, we analysed the structural similarity of the S protein between SARS-CoV-2 and other SARS-related coronaviruses. The S1 domain of the unclassified coronavirus RaTG13 was structurally very similar to that of SARS-CoV-2, implying that RaTG13 could be the origin of SARS-CoV-2.

Subject Areas

angiotensin-converting enzyme 2; SARS-CoV-2; spike protein

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