Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses

YoungJoon Park; Ju Won Ahn; Sojung Hwang; Kyoung Su Sung; Jaejoon Lim; KyuBum Kwack

doi:10.20944/preprints202003.0409.v1

Submitted:

26 March 2020

Posted:

27 March 2020

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Structural Similarity Analysis of the Spike Protein of SARS-CoV-2 and Other SARS-related Coronaviruses

YoungJoon Park,Ju Won Ahn,Sojung Hwang,Kyoung Su Sung,Jaejoon Lim,KyuBum Kwack^*

Submitted:

26 March 2020

Posted:

27 March 2020

Read the latest preprint version here

Part of the Following Collection

Preprints on COVID-19 and SARS-CoV-2

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has high infectivity in humans, attributed to the strong affinity of its spike (S) protein to angiotensin-converting enzyme 2. Here, we analysed the structural similarity of the S protein between SARS-CoV-2 and other SARS-related coronaviruses. The S1 domain of the unclassified coronavirus RaTG13 was structurally very similar to that of SARS-CoV-2, implying that RaTG13 could be the origin of SARS-CoV-2.

Keywords:

angiotensin-converting enzyme 2

;

SARS-CoV-2

;

spike protein

Subject:

Biology and Life Sciences - Virology

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