Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

What Determines Spontaneous Physical Activity in Patients with Parkinson’s Disease?

Version 1 : Received: 25 March 2020 / Approved: 26 March 2020 / Online: 26 March 2020 (14:15:49 CET)
Version 2 : Received: 7 May 2020 / Approved: 7 May 2020 / Online: 7 May 2020 (13:05:08 CEST)

A peer-reviewed article of this Preprint also exists.

Gorzkowska, A.; Cholewa, J.; Małecki, A.; Klimkowicz-Mrowiec, A.; Cholewa, J. What Determines Spontaneous Physical Activity in Patients with Parkinson’s Disease? J. Clin. Med. 2020, 9, 1296. Gorzkowska, A.; Cholewa, J.; Małecki, A.; Klimkowicz-Mrowiec, A.; Cholewa, J. What Determines Spontaneous Physical Activity in Patients with Parkinson’s Disease? J. Clin. Med. 2020, 9, 1296.

Journal reference: Journal of Clinical Medicine 2020, 9
DOI: 10.3390/jcm9051296

Abstract

Physical activity (PA) is a factor that may have an influence on the symptoms of Parkinson’s disease (PD). The aim of this study was to identify the potential determinants of spontaneous PA in the PD patient group. 134 PD patients aged 65.2±9.2 years, Hoehn-Yahr scale ≤ 4, Mini Mental State Examinaton (MMSE) ≥ 24 were examined. For the study purposes, the authors analyzed: age, sex, education, history of PD, dopaminergic treatment, the severity of PD symptoms using Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn-Yahr scale. Additionally all participants were evaluated through a set of scales for specific neuropsychiatric symptoms including: depression, anxiety, apathy, fatigue and sleep disorders. An analysis of linear regression was used with backward elimination. In the total explanatory model, 12% of the variability in activity (R2=0.125; F(16.133)=2.185; p<0.01), the significant predictor was starting therapy with the dopamine agonist (DA) (β= 0.420; t= 4.068; p=0.000), which was associated with a longer duration of moderate PA. In the total explanatory model, for more than 13% of the variance in time spent sitting (R2=0.135; F(16.130)=2.267; p<0.01), the significant predictors were secondary education and the results of the UPDRS. The patients with secondary and vocational education, those starting treatment with DA and those with a less severe degree of Parkinson’s symptoms (UPDRS) spent less time sitting in a day. It is possible to identify determinants of spontaneous PA. It may elucidate consequences in terms of influence on modifiable conditions of PA and the proper approach to patients with unmodifiable PA factors.

Subject Areas

Parkinson’s disease; physical activity; sedentary way; non-motor symptoms; apathy; dopaminergic therapy

Comments (1)

Comment 1
Received: 7 May 2020
Commenter: English correction
Commenter's Conflict of Interests: Author
Comment: Minor additions have been made to the first version
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