Preprint Article Version 1 This version is not peer-reviewed

Potential Pathogenesis of Multiple Organ Injury in COVID-19

Version 1 : Received: 19 March 2020 / Approved: 20 March 2020 / Online: 20 March 2020 (07:01:44 CET)

How to cite: Guo, L.; Yu, K.; Li, D.; Yang, H.; Liu, L.; Fan, J.; Sun, N.; Yang, X. Potential Pathogenesis of Multiple Organ Injury in COVID-19. Preprints 2020, 2020030308 (doi: 10.20944/preprints202003.0308.v1). Guo, L.; Yu, K.; Li, D.; Yang, H.; Liu, L.; Fan, J.; Sun, N.; Yang, X. Potential Pathogenesis of Multiple Organ Injury in COVID-19. Preprints 2020, 2020030308 (doi: 10.20944/preprints202003.0308.v1).

Abstract

Novel coronavirus (COVID-19) can lead to multiple organ injuries such as acute respiratory distress syndrome (ARDS), acute renal injury (AKI) and so on. ACE2 is an important part of the renin-angiotensin system (RAS) and a key protein needed for COVID-19 to invade cells. First of all, we searched the HPA, GTEx and FANTOM5 Databases and found that the expression of ACE2 in kidney tissue was significantly higher than that in lung tissue. Then, by searching the Nephroseq Database, it is further verified that ACE2 is highly expressed in renal tissue and plays a protective role in renal tissue. However, current studies have found that the incidence of AKI caused by COVID-19 is much lower than that of ARDS. Because of this, we further searched the proteins interacting with ACE2 protein through the STING Database and analyzed the expression of tissue protein mRNA in the HPA Database. It was noted that AGTR2 mRNA was highly expressed in lung tissue, but low in kidney tissue, and hard tissue specificity in lung tissue. Through further research, it is found that AGTR2 plays a major role in the development of pulmonary fibrosis. Therefore, AGTR2 may be a key protein in COVID-19 pneumonia, and AGTR2 may be a potential new therapeutic target for the treatment of COVID-19 patients.

Supplementary and Associated Material

Subject Areas

AGTR2; ACE2; COVID-19

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