Preprint Review Version 1 This version is not peer-reviewed

A G(enomic)P(ositioning)S(ystem) for Plant RNAPII Transcription

Version 1 : Received: 17 March 2020 / Approved: 18 March 2020 / Online: 18 March 2020 (17:14:28 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: Trends in Plant Science 2020
DOI: 10.1016/j.tplants.2020.03.005

Abstract

Post-translational modifications (PTMs) of histone residues shape the landscape of gene expression by modulating the dynamic process of RNAPII transcription. The contribution of particular histone modifications to the definition of distinct RNAPII transcription stages remains poorly characterized in plants. Chromatin Immuno-precipitation combined with next-generation sequencing (ChIP-seq) resolves the genomic distribution of histone modifications. Here, we review histone PTM ChIP-seq data in Arabidopsis thaliana and find support for a Genomic Positioning System (GPS) that guides RNAPII transcription. We review the roles of histone PTM “readers”, “writers” and “erasers”, with a focus on the regulation of gene expression and biological functions in plants. The distinct functions of RNAPII transcription during the plant transcription cycle may in part rely on the characteristic histone PTMs profiles that distinguish transcription stages.

Subject Areas

Histone PTM; RNA Polymerase II; ChIP-seq; chromatin; epigenetics; transcriptional interference; plant; Transcription Cycle; Transcription

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