Preprint Communication Version 2 This version is not peer-reviewed

Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection

Version 1 : Received: 10 March 2020 / Approved: 11 March 2020 / Online: 11 March 2020 (10:40:09 CET)
Version 2 : Received: 5 April 2020 / Approved: 6 April 2020 / Online: 6 April 2020 (14:09:34 CEST)

How to cite: Xia, N.; Wang, G.; Gong, W. Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection. Preprints 2020, 2020030184 (doi: 10.20944/preprints202003.0184.v2). Xia, N.; Wang, G.; Gong, W. Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection. Preprints 2020, 2020030184 (doi: 10.20944/preprints202003.0184.v2).

Abstract

To date, viral RNA detection is almost the only way to confirm SARS-CoV-2infectionin practice.However, variousreasons can cause low sensitivity for RNA detection, and thisposes aserious challenge to disease control. We tested the performance of detecting total antibody(Ab) and IgM levels in serum by the methods of chemiluminescence, enzyme-linked immunosorbent assay (ELISA), and colloidal golddetection. The datashowed that the sensitivity and specificity for detecting total Ab and IgM levels were high by all three methods, and the sensitivity was higher for detecting total Ab than for detecting IgM. Evidence from studieshas shown thatviral RNA testingcombinedwith serological testing could increase the diagnostic sensitivity while maintaining a high specificity. Specific serology testsfor SARS-CoV-2 havegreat value for clinical practice and public health.

Subject Areas

SARS-CoV-2; diagnosis; antibody; serology; screening

Comments (1)

Comment 1
Received: 6 April 2020
Commenter: Ning-Shao Xia
Commenter's Conflict of Interests: Author
Comment: 1.Editing the language. 2.Updating the reference.
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