Version 1
: Received: 10 March 2020 / Approved: 11 March 2020 / Online: 11 March 2020 (10:40:09 CET)
Version 2
: Received: 5 April 2020 / Approved: 6 April 2020 / Online: 6 April 2020 (14:09:34 CEST)
How to cite:
Xia, N.; Wang, G.; Gong, W. Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection. Preprints2020, 2020030184. https://doi.org/10.20944/preprints202003.0184.v2
Xia, N.; Wang, G.; Gong, W. Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection. Preprints 2020, 2020030184. https://doi.org/10.20944/preprints202003.0184.v2
Xia, N.; Wang, G.; Gong, W. Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection. Preprints2020, 2020030184. https://doi.org/10.20944/preprints202003.0184.v2
APA Style
Xia, N., Wang, G., & Gong, W. (2020). <strong>Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection</strong>. Preprints. https://doi.org/10.20944/preprints202003.0184.v2
Chicago/Turabian Style
Xia, N., Gui-Qiang Wang and Wen-Feng Gong. 2020 "<strong>Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection</strong>" Preprints. https://doi.org/10.20944/preprints202003.0184.v2
Abstract
To date, viral RNA detection is almost the only way to confirm SARS-CoV-2infectionin practice.However, variousreasons can cause low sensitivity for RNA detection, and thisposes aserious challenge to disease control. We tested the performance of detecting total antibody(Ab) and IgM levels in serum by the methods of chemiluminescence, enzyme-linked immunosorbent assay (ELISA), and colloidal golddetection. The datashowed that the sensitivity and specificity for detecting total Ab and IgM levels were high by all three methods, and the sensitivity was higher for detecting total Ab than for detecting IgM. Evidence from studieshas shown thatviral RNA testingcombinedwith serological testing could increase the diagnostic sensitivity while maintaining a high specificity. Specific serology testsfor SARS-CoV-2 havegreat value for clinical practice and public health.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Ning-Shao Xia
Commenter's Conflict of Interests: Author
2.Updating the reference.