Preprint Brief Report Version 1 This version is not peer-reviewed

Predicting the Angiotensin Converting Enzyme 2 (ACE2) Utilizing Capability as the Receptor of SARS-CoV-2

Version 1 : Received: 4 March 2020 / Approved: 5 March 2020 / Online: 5 March 2020 (12:12:38 CET)

How to cite: Qiu, Y.; Zhao, Y.; Wang, Q.; Li, J.; ZHou, Z.; Liao, C.; Ge, X. Predicting the Angiotensin Converting Enzyme 2 (ACE2) Utilizing Capability as the Receptor of SARS-CoV-2. Preprints 2020, 2020030091 (doi: 10.20944/preprints202003.0091.v1). Qiu, Y.; Zhao, Y.; Wang, Q.; Li, J.; ZHou, Z.; Liao, C.; Ge, X. Predicting the Angiotensin Converting Enzyme 2 (ACE2) Utilizing Capability as the Receptor of SARS-CoV-2. Preprints 2020, 2020030091 (doi: 10.20944/preprints202003.0091.v1).

Abstract

SARS-CoV-2, the newly identified human coronavirus causing severe pneumonia epidemic, was probably originated from Chinese horseshoe bats. However, direct transmission of the virus from bats to humans is unlikely due to lack of direct contact, implying the existence of unknown intermediate hosts. Angiotensin converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2, but only ACE2s of certain species can be utilized by SARS-CoV-2. Here, we evaluated and ranked the receptor-utilizing capability of ACE2s from various species by phylogenetic clustering and sequence alignment with the currently known ACE2s utilized by SARS-CoV-2, predicting potential intermediate hosts of SARS-CoV-2.

Subject Areas

SARS-CoV-2; coronavirus; angiotensin converting enzyme 2 (ACE2); receptor utilization; phylogenetic analysis.

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