Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing

Sara Invitto; Alberto Grasso; Dario Domenico Lofrumento; Vincenzo Ciccarese; Pasquale Paladini; Angela Paladini; Raffaella Marulli; Vilfredo De Pascalis; Matteo Polsinelli; Giuseppe Placidi

doi:10.20944/preprints202003.0069.v1

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preprints.org > social sciences > cognitive science > doi: 10.20944/preprints202003.0069.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing

Sara Invitto

^* ,

Alberto Grasso

Dario Domenico Lofrumento

Version 1 : Received: 3 March 2020 / Approved: 4 March 2020 / Online: 4 March 2020 (14:56:14 CET)

How to cite: Invitto, S.; Grasso, A.; Lofrumento, D.D.; Ciccarese, V.; Paladini, P.; Paladini, A.; Marulli, R.; De Pascalis, V.; Polsinelli, M.; Placidi, G. Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing. Preprints 2020, 2020030069. https://doi.org/10.20944/preprints202003.0069.v1 Invitto, S.; Grasso, A.; Lofrumento, D.D.; Ciccarese, V.; Paladini, P.; Paladini, A.; Marulli, R.; De Pascalis, V.; Polsinelli, M.; Placidi, G. Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing. Preprints 2020, 2020030069. https://doi.org/10.20944/preprints202003.0069.v1

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MDPI and ACS Style

Invitto, S.; Grasso, A.; Lofrumento, D.D.; Ciccarese, V.; Paladini, P.; Paladini, A.; Marulli, R.; De Pascalis, V.; Polsinelli, M.; Placidi, G. Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing. Preprints 2020, 2020030069. https://doi.org/10.20944/preprints202003.0069.v1

APA Style

Invitto, S., Grasso, A., Lofrumento, D.D., Ciccarese, V., Paladini, P., Paladini, A., Marulli, R., De Pascalis, V., Polsinelli, M., & Placidi, G. (2020). Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing. Preprints. https://doi.org/10.20944/preprints202003.0069.v1

Chicago/Turabian Style

Invitto, S., Matteo Polsinelli and Giuseppe Placidi. 2020 "Chemosensory Event-related Potentials in 3M Syndrome Infants: An Early Biomarker Based on EEG Signal Processing" Preprints. https://doi.org/10.20944/preprints202003.0069.v1

Abstract

3M syndrome is a rare disorder that involves the gene CUL7. CUL7 modulates odour detection, conditions the olfactory response (OR) and plays a role in olfactory system development. Despite this involvement, there are no direct studies on olfactory functional effects in 3M syndrome. The purpose of the present work was to analyse the cortical OR, through chemosensory event-related potentials (CSERP) and power spectra calculated by electroencephalogram (EEG) signals recorded in 3M infants: two twins (3M-N) and an additional subject (3M-O). The results suggest that olfactory processing is diversified. Comparison of N1 and LPC components indicated substantial differences in 3M syndrome that may be a consequence of a modified olfactory processing pattern. Moreover, the presence of delta rhythms in 3M-O and 3M-N clearly indicates their involvement with OR, since the delta rhythm is closely connected to chemosensory perception, in particular to olfactory perception.

Keywords

CSERP; OERP; EEG; Spectra power; 3M syndrome; rare disease

Subject

Social Sciences, Cognitive Science

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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