Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chemosensory Event-related Potentials in 3M Syndrome Infants: An early Biomarker Based on EEG Signal Processing

Version 1 : Received: 3 March 2020 / Approved: 4 March 2020 / Online: 4 March 2020 (11:38:24 CET)

A peer-reviewed article of this Preprint also exists.

Invitto, S.; Grasso, A.; Lofrumento, D.D.; Ciccarese, V.; Paladini, A.; Paladini, P.; Marulli, R.; Pascalis, V.D.; Polsinelli, M.; Placidi, G. Chemosensory Event-Related Potentials and Power Spectrum could be A Possible Biomarker in 3M Syndrome Infants? Brain Sci. 2020, 10, 201. Invitto, S.; Grasso, A.; Lofrumento, D.D.; Ciccarese, V.; Paladini, A.; Paladini, P.; Marulli, R.; Pascalis, V.D.; Polsinelli, M.; Placidi, G. Chemosensory Event-Related Potentials and Power Spectrum could be A Possible Biomarker in 3M Syndrome Infants? Brain Sci. 2020, 10, 201.

Journal reference: Brain Sci. 2020, 10, 201
DOI: 10.3390/brainsci10040201

Abstract

3M syndrome is a rare disorder that involves the gene CUL7. CUL7 modulates odour detection, conditions the olfactory response (OR) and plays a role in olfactory system development. Despite this involvement, there are no direct studies on olfactory functional effects in 3M syndrome. The purpose of the present work was to analyse the cortical OR, through chemosensory event-related potentials (CSERP) and power spectra calculated by electroencephalogram (EEG) signals recorded in 3M infants: two twins (3M-N) and an additional subject (3M-O). The results suggest that olfactory processing is diversified. Comparison of N1 and LPC components indicated substantial differences in 3M syndrome that may be a consequence of a modified olfactory processing pattern. Moreover, the presence of delta rhythms in 3M-O and 3M-N clearly indicates their involvement with OR, since the delta rhythm is closely connected to chemosensory perception, in particular to olfactory perception.

Subject Areas

CSERP; OERP; EEG; spectra power; olfactory system; 3M syndrome; rare disease

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