Preprint Review Version 1 This version is not peer-reviewed

An Antiviral Process Targeting HTLV-1: The Complex Relationship between HTLV-1 and Nonsense-mediated mRNA Decay

Version 1 : Received: 3 March 2020 / Approved: 4 March 2020 / Online: 4 March 2020 (10:18:27 CET)

A peer-reviewed article of this Preprint also exists.

Prochasson, L.; Jalinot, P.; Mocquet, V. The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD). Pathogens 2020, 9, 287. Prochasson, L.; Jalinot, P.; Mocquet, V. The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD). Pathogens 2020, 9, 287.

Journal reference: Pathogens 2020, 9, 287
DOI: 10.3390/pathogens9040287

Abstract

Before the adaptive immune response is established, retroviruses can be targeted by several cellular host factors at different stages of the viral replication cycle. This intrinsic immunity relies on a large diversity of antiviral processes. In the case of HTLV-1 infection, these active innate host defence mechanisms are debated. Among these mechanisms, we focused on a RNA decay pathway called nonsense-mediated mRNA decay (NMD), which can target multiple viral RNAs, including HTLV-1 unspliced RNA, as it has been recently demonstrated. NMD is a cotranslational process that depends on the RNA helicase UPF1 and regulates the expression of multiple types of host mRNAs. RNA sensitivity to NMD depends on mRNA organization and the ribonucleoprotein (mRNP) composition. HTLV-1 has evolved several means to evade the NMD threat, leading to NMD inhibition. In the early steps of infection, NMD inhibition favours the production of HTLV-1 infectious particles, which may contribute to the survival of the most fit clones despite genome instability; however, its direct long-term impact remains to be investigated.

Subject Areas

HTLV-1; retrovirus; NMD; UPF1; antiviral

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