Preprint Review Version 1 This version is not peer-reviewed

Towards More Powerful Antibodies for Fibroblast Growth Factor Receptors in Breast Cancer

Version 1 : Received: 24 February 2020 / Approved: 26 February 2020 / Online: 26 February 2020 (01:41:54 CET)

A peer-reviewed article of this Preprint also exists.

Navid, S.; Fan, C.; O. Flores-Villanueva, P.; Generali, D.; Li, Y. The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments. Int. J. Mol. Sci. 2020, 21, 2011. Navid, S.; Fan, C.; O. Flores-Villanueva, P.; Generali, D.; Li, Y. The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments. Int. J. Mol. Sci. 2020, 21, 2011.

Journal reference: Int. J. Mol. Sci. 2020, 21, 2011
DOI: 10.3390/ijms21062011

Abstract

Breast cancer (BC) is the most frequent form of malignancy and the second only to lung cancer as common cause of cancer-causing deaths in women. Notwithstanding many progresses in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet patients‘ needs, a better knowledge of the molecular biology leading to the disease unfolds the possibility to project more precise compounds or antibodies targeting definite alteration at the molecular level expressed in cancer cells of patients or as antigens on the surface of cell membranes. Fibroblast growth factor receptor (FGFR) is a druggable target -which is activated by its own ligands -namely the Fibroblast Growth Factors (FGFs). This pathway provides a vast range of interesting molecular targets pursued at different levels of clinical investigation. Herein we provide an update on the knowledge on genetic alterations of the receptors in breast cancer, their role in tumorigenesis and the most recent drugs against this particular receptor to treat the disease.

Subject Areas

metastatic breast cancer; targeted therapies; fibroblast growth factors receptors drugs

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