Version 1
: Received: 19 February 2020 / Approved: 20 February 2020 / Online: 20 February 2020 (07:07:36 CET)
Version 2
: Received: 26 February 2020 / Approved: 29 February 2020 / Online: 29 February 2020 (11:24:04 CET)
Version 3
: Received: 19 March 2020 / Approved: 20 March 2020 / Online: 20 March 2020 (09:14:58 CET)
Version 4
: Received: 28 March 2020 / Approved: 30 March 2020 / Online: 30 March 2020 (04:56:42 CEST)
Version 5
: Received: 13 June 2020 / Approved: 14 June 2020 / Online: 14 June 2020 (17:43:37 CEST)
How to cite:
Yan, S.; Wan, Y.; Zhang, Y.; An, S.; Yang, K.; Xu, H.; Gan, T.; Cao, W.; Liu, Q. The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus. Preprints2020, 2020020289. https://doi.org/10.20944/preprints202002.0289.v2
Yan, S.; Wan, Y.; Zhang, Y.; An, S.; Yang, K.; Xu, H.; Gan, T.; Cao, W.; Liu, Q. The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus. Preprints 2020, 2020020289. https://doi.org/10.20944/preprints202002.0289.v2
Yan, S.; Wan, Y.; Zhang, Y.; An, S.; Yang, K.; Xu, H.; Gan, T.; Cao, W.; Liu, Q. The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus. Preprints2020, 2020020289. https://doi.org/10.20944/preprints202002.0289.v2
APA Style
Yan, S., Wan, Y., Zhang, Y., An, S., Yang, K., Xu, H., Gan, T., Cao, W., & Liu, Q. (2020). The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus. Preprints. https://doi.org/10.20944/preprints202002.0289.v2
Chicago/Turabian Style
Yan, S., Weiguo Cao and Qiuyun Liu. 2020 "The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus" Preprints. https://doi.org/10.20944/preprints202002.0289.v2
Abstract
The current pneumonia epidemic in China could evolve into a pandemic on a global scale if not effectively contained. The 2019-nCoV possesses a 61-amino acid open reading frame resembling SARS-CoV virulence factor - ORF6 peptide. The isoleucine content is 15.9% in ORF6 of SARS-CoV versus 16.4% of that in 2019-nCoV. Given the proton affinity in the carbonyl oxygen in isoleucine, augmented proton traffic can enhance proton-ion antiport and prompt cell swelling. As the content of essential amino acids in the open reading frame of 2019-nCoV reaches 57.4%, a starch/vitamin diet served for short period of time does not give rise to essential amino acids and halts virion production, which could be adopted as prophylactic approach of many viral infections. Plant-based diet or fasting/boiled rice water can also minimize the intake of essential amino acids or all amino acids respectively. Calorie restriction has been confirmed in animal studies to extend lifespan, and its underlying mechanism is not fully known. Furthermore, several proteins of 2019-nCoV possess high valine plus glycine content, which is implicated in heart disease.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Qiuyun Liu
Commenter's Conflict of Interests: Author