Preprint Article Version 1 This version is not peer-reviewed

Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

Version 1 : Received: 10 February 2020 / Approved: 11 February 2020 / Online: 11 February 2020 (09:20:00 CET)

How to cite: Kim, Y.J.; Cha, H.J. Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Preprints 2020, 2020020137 (doi: 10.20944/preprints202002.0137.v1). Kim, Y.J.; Cha, H.J. Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Preprints 2020, 2020020137 (doi: 10.20944/preprints202002.0137.v1).

Abstract

In present study, the effect of Inonotus Obliquus extracts used in traditional medicine was investigated on the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown our results, extracts of Inonotus Obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus Obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress exposed normal human dermal fibroblasts. The results suggest that Inonotus Obliquus extracts decreased MMP1 expression using decreasing AP-1 transcriptional activity and phospho-JNK. Therefore, Inonotus Obliquus extracts has potential to reduce formation of wrinkle and to use as a cosmetic ingredient.

Subject Areas

Inonotus Obliquus extracts; MMP1; human dermal fibroblasts; JNK; AP-1

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