Version 1
: Received: 10 February 2020 / Approved: 11 February 2020 / Online: 11 February 2020 (09:20:00 CET)
How to cite:
Kim, Y.J.; Cha, H.J. Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Preprints2020, 2020020137. https://doi.org/10.20944/preprints202002.0137.v1.
Kim, Y.J.; Cha, H.J. Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Preprints 2020, 2020020137. https://doi.org/10.20944/preprints202002.0137.v1.
Cite as:
Kim, Y.J.; Cha, H.J. Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Preprints2020, 2020020137. https://doi.org/10.20944/preprints202002.0137.v1.
Kim, Y.J.; Cha, H.J. Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Preprints 2020, 2020020137. https://doi.org/10.20944/preprints202002.0137.v1.
Abstract
In present study, the effect of Inonotus Obliquus extracts used in traditional medicine was investigated on the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown our results, extracts of Inonotus Obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus Obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress exposed normal human dermal fibroblasts. The results suggest that Inonotus Obliquus extracts decreased MMP1 expression using decreasing AP-1 transcriptional activity and phospho-JNK. Therefore, Inonotus Obliquus extracts has potential to reduce formation of wrinkle and to use as a cosmetic ingredient.
Keywords
Inonotus Obliquus extracts; MMP1; human dermal fibroblasts; JNK; AP-1
Subject
LIFE SCIENCES, Biochemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
