Version 1
: Received: 30 January 2020 / Approved: 31 January 2020 / Online: 31 January 2020 (05:18:15 CET)
How to cite:
Ohannesian, N.; Gunawardhana, D.; Misbah, I.; Rakhshandehroo, M.; Lin, S.H.; Shih, W. Commercial and Emerging Technologies for Cancer Diagnosis and Prognosis Based on Exosomal Biomarkers. Preprints2020, 2020010379
Ohannesian, N.; Gunawardhana, D.; Misbah, I.; Rakhshandehroo, M.; Lin, S.H.; Shih, W. Commercial and Emerging Technologies for Cancer Diagnosis and Prognosis Based on Exosomal Biomarkers. Preprints 2020, 2020010379
Ohannesian, N.; Gunawardhana, D.; Misbah, I.; Rakhshandehroo, M.; Lin, S.H.; Shih, W. Commercial and Emerging Technologies for Cancer Diagnosis and Prognosis Based on Exosomal Biomarkers. Preprints2020, 2020010379
APA Style
Ohannesian, N., Gunawardhana, D., Misbah, I., Rakhshandehroo, M., Lin, S.H., & Shih, W. (2020). Commercial and Emerging Technologies for Cancer Diagnosis and Prognosis Based on Exosomal Biomarkers. Preprints. https://doi.org/
Chicago/Turabian Style
Ohannesian, N., Steven H. Lin and Wei-Chuan Shih. 2020 "Commercial and Emerging Technologies for Cancer Diagnosis and Prognosis Based on Exosomal Biomarkers" Preprints. https://doi.org/
Abstract
Exosomes are nano-sized extracellular vesicles excreted by mammalian cells that circulate freely in the bloodstream of living organisms. Exosomes have a lipid bilayer that encloses genetic material used in intracellular communication (e.g., double-stranded DNA, micro-RNAs, and messenger RNA). Recent evidence suggests that dysregulation of this genetic content within exosomes has a major role in tumor progression and in the surrounding microenvironment. Motivated by this discovery, we focused here on using exosomal biomarkers as a diagnostic and prognostic tool for cancer. In this review, we discuss recently discovered exosome-derived proteomic and genetic biomarkers used in cancer diagnosis and prognosis. Although several genetic biomarkers have been validated for their diagnostic values, proteomic biomarkers are still being actively pursued. We discuss both commercial technologies and emerging technologies for exosome isolation and analysis.
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
