Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association between Post-Diagnosis Particulate Matter Exposure Among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea

Kyae Hyung Kim
ORCID logo ,
Seulggie Choi
,
Kyuwoong Kim
,
Jooyoung Chang
ORCID logo ,
Sung Min Kim
,
Seong Rae Kim
ORCID logo ,
Yoosun Cho
,
Gyeongsil Lee
,
Joung Sik Son
ORCID logo ,
Sang Min Park
*
Version 1 : Received: 20 January 2020 / Approved: 21 January 2020 / Online: 21 January 2020 (11:10:42 CET)

How to cite: Kim, K.H.; Choi, S.; Kim, K.; Chang, J.; Kim, S.M.; Kim, S.R.; Cho, Y.; Lee, G.; Son, J.S.; Park, S.M. Association between Post-Diagnosis Particulate Matter Exposure Among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea. Preprints 2020, 2020010241. https://doi.org/10.20944/preprints202001.0241.v1 Kim, K.H.; Choi, S.; Kim, K.; Chang, J.; Kim, S.M.; Kim, S.R.; Cho, Y.; Lee, G.; Son, J.S.; Park, S.M. Association between Post-Diagnosis Particulate Matter Exposure Among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea. Preprints 2020, 2020010241. https://doi.org/10.20944/preprints202001.0241.v1

Abstract

Abstract: Cancer survivors are at an increased risk for cardiovascular disease (CVD). However, the association between particulate matter (PM) and CVD risk among cancer survivors (alive >5 years since diagnosis) is unclear. We investigated the risk of CVD among 40,899 cancer survivors within the Korean National Health Insurance Service database. Exposure to PM was determined by assessing yearly average PM levels obtained from the Air Korea database from 2008 to 2011. PMs with sizes <2.5 (PM2.5), <10 (PM10), or 2.5-10 (PM2.5-10) μm in diameter were compared, with each PM level exposure further divided into quintiles. Patients were followed up from January 2012 to date of CVD event, death, or December 2017, whichever came earliest. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated using Cox proportional hazards regression by PM exposure levels. Compared with cancer survivors in the lowest quintile of PM2.5 exposure, those within the highest quintile had a greater risk for CVD (aHR 1.31, 95% CI 1.07-1.59). Conversely, increasing PM10 and PM2.5-10 levels were not associated with increased CVD risk (p for trend 0.078 and 0.361, respectively). Cancer survivors who reduce PM2.5 exposure may reduce their risk of developing CVD.

Keywords

cardiovascular disease; particulate matter; cancer survivor; metropolitan area

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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