Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Altertoxins with Quorum Sensing Inhibitory Activities from the Marine-Derived Fungus Cladosporium sp. KFD33

Version 1 : Received: 30 December 2019 / Approved: 31 December 2019 / Online: 31 December 2019 (02:31:16 CET)

A peer-reviewed article of this Preprint also exists.

Zhang, F.; Zhou, L.; Kong, F.; Ma, Q.; Xie, Q.; Li, J.; Dai, H.; Guo, L.; Zhao, Y. Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33. Mar. Drugs 2020, 18, 67. Zhang, F.; Zhou, L.; Kong, F.; Ma, Q.; Xie, Q.; Li, J.; Dai, H.; Guo, L.; Zhao, Y. Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33. Mar. Drugs 2020, 18, 67.

Journal reference: Mar. Drugs 2020, 18, 67
DOI: 10.3390/md18010067

Abstract

Five new perylenequinone derivatives, altertoxins VIII-XII (1-5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1-6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.

Subject Areas

Cladosporium sp.; altertoxins; quorum sensing inhibitory activity

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