Zhang, F.; Zhou, L.; Kong, F.; Ma, Q.; Xie, Q.; Li, J.; Dai, H.; Guo, L.; Zhao, Y. Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33. Mar. Drugs2020, 18, 67.
Zhang, F.; Zhou, L.; Kong, F.; Ma, Q.; Xie, Q.; Li, J.; Dai, H.; Guo, L.; Zhao, Y. Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33. Mar. Drugs 2020, 18, 67.
Zhang, F.; Zhou, L.; Kong, F.; Ma, Q.; Xie, Q.; Li, J.; Dai, H.; Guo, L.; Zhao, Y. Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33. Mar. Drugs2020, 18, 67.
Zhang, F.; Zhou, L.; Kong, F.; Ma, Q.; Xie, Q.; Li, J.; Dai, H.; Guo, L.; Zhao, Y. Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33. Mar. Drugs 2020, 18, 67.
Abstract
Five new perylenequinone derivatives, altertoxins VIII-XII (1-5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1-6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
Keywords
Cladosporium sp.; altertoxins; quorum sensing inhibitory activity
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
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