Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program

Version 1 : Received: 29 December 2019 / Approved: 30 December 2019 / Online: 30 December 2019 (09:35:38 CET)

How to cite: Sica, A.; Sagnelli, C.; Fasano, M.; Spada, A.; Munier, G.; Famiglietti, V.; Dodaro, C.A.; Calogero, A.; Ciccozzi, M.; Sagnelli, E.; Amarelli, C.; Maiello, C.; Casale, B. Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program. Preprints 2019, 2019120394 (doi: 10.20944/preprints201912.0394.v1). Sica, A.; Sagnelli, C.; Fasano, M.; Spada, A.; Munier, G.; Famiglietti, V.; Dodaro, C.A.; Calogero, A.; Ciccozzi, M.; Sagnelli, E.; Amarelli, C.; Maiello, C.; Casale, B. Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program. Preprints 2019, 2019120394 (doi: 10.20944/preprints201912.0394.v1).

Abstract

The incidence of post transplantation lymphoproliferative disorders (PTLDs) and other neoplasms in organ transplant patients is higher than in the non-transplanted population. This event is more frequent in older subjects, due, at least in part, to the immune dysfunction induced by immunosuppressants administered to prevent rejection. Alterations of the immune system mechanisms of protection against carcinogenesis appear to be the key role in the in the pathogenesis of these neoplasms. The data of our study on the incidence of neoplasms occurred during a long-term follow-up in an elderly population after they underwent cardiac transplantation. This study gives, also evidence of the favorable effect of physical activity programs on cardiorespiratory and psychomotor function.

Subject Areas

physical activity; elderly population; mediastinal lymphomas; cardiac transplantation

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