Strategies to Combat Persistent Infectious Diseases

Olga Pacios; Lucia Blasco; Ines Bleriot; Laura Fernandez-Garcia; Monica Gonzalez-Bardanca; Anton Ambroa; Germán Bou; Maria Lopez-Diaz; Maria Tomas

doi:10.20944/preprints201912.0342.v1

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints201912.0342.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Strategies to Combat Persistent Infectious Diseases

Olga Pacios

Lucia Blasco

Ines Bleriot

Laura Fernandez-Garcia

Monica Gonzalez-Bardanca

Version 1 : Received: 24 December 2019 / Approved: 25 December 2019 / Online: 25 December 2019 (09:33:57 CET)

A peer-reviewed article of this Preprint also exists.

Pacios, O.; Blasco, L.; Bleriot, I.; Fernandez-Garcia, L.; González Bardanca, M.; Ambroa, A.; López, M.; Bou, G.; Tomás, M. Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases. Antibiotics 2020, 9, 65. Pacios, O.; Blasco, L.; Bleriot, I.; Fernandez-Garcia, L.; González Bardanca, M.; Ambroa, A.; López, M.; Bou, G.; Tomás, M. Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases. Antibiotics 2020, 9, 65.

Abstract

Antibiotic failure is one of the most worrying health problems worldwide. Nowadays we are facing an international crisis where several issues are involved: new antibiotics are not being discovered any longer, resistance mechanisms become spread in nearly every clinical isolate of bacteria and the appearance of recurrent infections caused by persistent bacteria complicates the overcoming of infections. In this context, it has been explored new anti-infectious strategies against MDR and persistent bacteria as well as the rescue of FDA-approved compounds (drug repurposing). Among the highlighted new anti-infectious strategies we find anti-microbial peptides, anti-virulence compounds, phage therapy and new molecules. On the other hand, as drugs of repurposing that have been described, we have anti-inflammatory compounds, anti-psychotics, anti-helmintic drugs, anti-cancerous and statins.

Keywords

Anti-MDR strategies; anti-persistent treatments; drug repurposing

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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