Preprint Review Version 1 This version is not peer-reviewed

Strategies to Combat Persistent Infectious Diseases

Version 1 : Received: 24 December 2019 / Approved: 25 December 2019 / Online: 25 December 2019 (09:33:57 CET)

How to cite: Pacios, O.; Blasco, L.; Bleriot, I.; Fernandez-Garcia, L.; Gonzalez-Bardanca, M.; Ambroa, A.; Bou, G.; Lopez-Diaz, M.; Tomas, M. Strategies to Combat Persistent Infectious Diseases. Preprints 2019, 2019120342 (doi: 10.20944/preprints201912.0342.v1). Pacios, O.; Blasco, L.; Bleriot, I.; Fernandez-Garcia, L.; Gonzalez-Bardanca, M.; Ambroa, A.; Bou, G.; Lopez-Diaz, M.; Tomas, M. Strategies to Combat Persistent Infectious Diseases. Preprints 2019, 2019120342 (doi: 10.20944/preprints201912.0342.v1).

Abstract

Antibiotic failure is one of the most worrying health problems worldwide. Nowadays we are facing an international crisis where several issues are involved: new antibiotics are not being discovered any longer, resistance mechanisms become spread in nearly every clinical isolate of bacteria and the appearance of recurrent infections caused by persistent bacteria complicates the overcoming of infections. In this context, it has been explored new anti-infectious strategies against MDR and persistent bacteria as well as the rescue of FDA-approved compounds (drug repurposing). Among the highlighted new anti-infectious strategies we find anti-microbial peptides, anti-virulence compounds, phage therapy and new molecules. On the other hand, as drugs of repurposing that have been described, we have anti-inflammatory compounds, anti-psychotics, anti-helmintic drugs, anti-cancerous and statins.

Subject Areas

Anti-MDR strategies; anti-persistent treatments; drug repurposing

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