Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

p75NTR as a Molecular Memory Switch

Version 1 : Received: 24 December 2019 / Approved: 25 December 2019 / Online: 25 December 2019 (03:27:36 CET)

How to cite: Ning, S.; Jorfi, M. p75NTR as a Molecular Memory Switch. Preprints 2019, 2019120333. Ning, S.; Jorfi, M. p75NTR as a Molecular Memory Switch. Preprints 2019, 2019120333.


In recent years, many molecular and environmental factors have been studied to understand how synaptic plasticity is modulated. Sleep, as an evolutionary conserved biological function, has shown to be a critical player for the consolidation and filtering of synaptic circuitry underlying memory traces. Although sleep disturbances do not alter normal memory consolidation, they may reflect fundamental circuit malfunctions that can play a significant role in exacerbating diseases, such as autism and Alzheimer’s disease. Very recently, scientists sought to answer part of this enigma and they identified p75 neurotrophic receptor (p75NTR) as a critical player in mediating impairments in hippocampal-dependent associative plasticity upon sleep deprivation. This paper will review the role of the p75NTR, critically discuss the impact and implications of this research as the bridge for sleep research and neurological diseases.


memory; p75NTR; synaptic plasticity; sleep deprivation


Biology and Life Sciences, Neuroscience and Neurology

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