Version 1
: Received: 9 December 2019 / Approved: 13 December 2019 / Online: 13 December 2019 (10:57:29 CET)
Version 2
: Received: 21 August 2020 / Approved: 21 August 2020 / Online: 21 August 2020 (11:26:33 CEST)
How to cite:
Lee, M. Investigating Strength that Comprehensive mRNA Expression Level of Prognostic Genes Influences on Patient Survival for Every Cancer Type. Preprints2019, 2019120183. https://doi.org/10.20944/preprints201912.0183.v1
Lee, M. Investigating Strength that Comprehensive mRNA Expression Level of Prognostic Genes Influences on Patient Survival for Every Cancer Type. Preprints 2019, 2019120183. https://doi.org/10.20944/preprints201912.0183.v1
Lee, M. Investigating Strength that Comprehensive mRNA Expression Level of Prognostic Genes Influences on Patient Survival for Every Cancer Type. Preprints2019, 2019120183. https://doi.org/10.20944/preprints201912.0183.v1
APA Style
Lee, M. (2019). Investigating Strength that Comprehensive mRNA Expression Level of Prognostic Genes Influences on Patient Survival for Every Cancer Type. Preprints. https://doi.org/10.20944/preprints201912.0183.v1
Chicago/Turabian Style
Lee, M. 2019 "Investigating Strength that Comprehensive mRNA Expression Level of Prognostic Genes Influences on Patient Survival for Every Cancer Type" Preprints. https://doi.org/10.20944/preprints201912.0183.v1
Abstract
This study aimed to rank cancers by the strength of relationship between comprehensive mRNA expression of the most harmful or protective genes and patient survival. Using TCGA dataset including RNA-SEQ and clinical data, we investigated not only gene specific prognostic availability, but also comprehensive prognostic availability of prognostic genes filtered by cox coefficient, and ranked cancers by specially designed prognostic indicator. Through Kaplan-Meier plots, we checked that cancers vary in the strength of influence of prognostic genes, and they follow as the rank. Developing treatment with method to reduce or increase expression of biomarkers for specific cancer which ranked bottom, it would be not efficient in high probability. The results of this study can be a scientific evidence for that.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
