Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Polarizability-dependent Sorting of Microparticles Using Continuous-flow Dielectrophoretic Chromatography with a Frequency Modulation Method

Jasper Giesler
,
Georg R. Pesch
* ORCID logo ,
Laura Weirauch
ORCID logo ,
Marc-Peter Schmidt
,
Jorg Thöming
,
Michael Baune
Version 1 : Received: 2 December 2019 / Approved: 3 December 2019 / Online: 3 December 2019 (11:30:11 CET)
Version 2 : Received: 16 December 2019 / Approved: 16 December 2019 / Online: 16 December 2019 (11:21:18 CET)

A peer-reviewed article of this Preprint also exists.

Giesler, J.; Pesch, G.R.; Weirauch, L.; Schmidt, M.-P.; Thöming, J.; Baune, M. Polarizability-Dependent Sorting of Microparticles Using Continuous-Flow Dielectrophoretic Chromatography with a Frequency Modulation Method. Micromachines 2020, 11, 38. Giesler, J.; Pesch, G.R.; Weirauch, L.; Schmidt, M.-P.; Thöming, J.; Baune, M. Polarizability-Dependent Sorting of Microparticles Using Continuous-Flow Dielectrophoretic Chromatography with a Frequency Modulation Method. Micromachines 2020, 11, 38.

Abstract

The separation of microparticles with respect to different properties such as size and material is a research field of great interest. Dielectrophoresis, a phenomenon which is capable of addressing multiple particle properties at once, can be used to perform a chromatographic separation. However, the selectivity of current dielectrophoretic particle chromatography (DPC) techniques is limited. Here we show a new approach for DPC based on differences in the dielectrophoretic mobilities and the crossover frequencies of polystyrene particles. Both differences are addressed by modulating the frequency of the electric field to generate positive and negative dielectrophoretic movement to achieve multiple trap and release cycles of the particles. A chromatographic separation of different particle sizes revealed a voltage dependency of this method. Additionally, we showed the frequency bandwidth influence on separation using one example. The DPC method developed was tested with model particles but offers possibilities to separate a broad range of plastic and metal microparticles or cells and to overcome currently existing limitations in selectivity.

Keywords

dielectrophoresis; microparticles; chromatography; separation; polarizability

Subject

Engineering, Industrial and Manufacturing Engineering

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1
Received: 16 December 2019
Commenter: Georg R. Pesch
Commenter's Conflict of Interests: Author
Comment: Updated version in response to first round of reviewers comments from submission.
Clarified the device operation principle and provided further experimental evidence of device operation.
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