Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Planar Cell Polarity: The Frizzled Homophobic Signal

Version 1 : Received: 20 September 2019 / Approved: 23 September 2019 / Online: 23 September 2019 (10:06:45 CEST)

How to cite: Gomes, J. Planar Cell Polarity: The Frizzled Homophobic Signal. Preprints 2019, 2019090265. Gomes, J. Planar Cell Polarity: The Frizzled Homophobic Signal. Preprints 2019, 2019090265.


The cell’s capacity to integrate and respond to spatial information is a crucial feature of morphogenesis and development. The Planar Cell Polarity (PCP) pathway is a signaling mechanism, widely conserved across metazoans, providing spatial orientation along the plane of an epithelium in morphogenic processes ranging from insect wing patterning to mammalian cochleae. Although the core genes involved in the PCP pathway have been molecularly identified in the 1990s, the PCP signaling mechanism remains controversial. In this article I discuss the main players and previous models of PCP signaling reported in the literature, and propose a new model. According to it PCP is established through an homophobic signal by transmembrane protein Frizzled (Fz): 1) a Fz signal in one cell repeals Fz itself in the adjacent cell, thereby generating symmetry breaking; 2) the instructive PCP signal is conveyed through Fz interaction with atypical cadherin Flamingo (Fmi). More broadly, homophobic signaling may represent a novel mechanism for cell-cell signaling of spatial information through modulation of cell adhesion rather than canonical ligand-receptor binding.


tissue polarity; Drosophila; epithelia; morphogenesis; cell adhesion


Biology and Life Sciences, Cell and Developmental Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0

Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.