Preprint Article Version 3 Preserved in Portico This version is not peer-reviewed

Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using FTIR-ATR Spectroscopy

Version 1 : Received: 11 September 2019 / Approved: 16 September 2019 / Online: 16 September 2019 (12:01:49 CEST)
Version 2 : Received: 14 July 2020 / Approved: 16 July 2020 / Online: 16 July 2020 (03:57:57 CEST)
Version 3 : Received: 2 August 2020 / Approved: 4 August 2020 / Online: 4 August 2020 (08:21:22 CEST)

How to cite: Ramanujam, P.; B, R.; S, G.; GR, R.; G, S.; S, M. Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using FTIR-ATR Spectroscopy. Preprints 2019, 2019090166 (doi: 10.20944/preprints201909.0166.v3). Ramanujam, P.; B, R.; S, G.; GR, R.; G, S.; S, M. Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using FTIR-ATR Spectroscopy. Preprints 2019, 2019090166 (doi: 10.20944/preprints201909.0166.v3).

Abstract

Acne vulgaris is a chronic skin disease, which occurs due to inflammation of the hair follicles and sebum producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P.acne. Human sebum is dominantly made up of 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P.acne over growth which induces monocytes and pro inflammatory cytokines attracts neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyper proliferation i.e., Acne vulgaris. The actual biomolecular changes due to acne vulgaris disease are present in the blood, in the sebum, and in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair tissue samples through acne biomarkers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters. This work represents a first step in the development of the analytical tool for future drug development.

Subject Areas

Acne Vulgaris; Hair tissue samples; Discrimination; FTIR-ATR

Comments (1)

Comment 1
Received: 4 August 2020
Commenter: PADMAVATHI RAMANUJAM
Commenter's Conflict of Interests: Author
Comment: Revisions are throughout the manuscript.
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