Working Paper Article Version 1 This version is not peer-reviewed

Food-Drug Interaction Between the Adlay Bran Oil and Drugs in Rats

Version 1 : Received: 8 September 2019 / Approved: 10 September 2019 / Online: 10 September 2019 (03:16:30 CEST)

How to cite: Yao, H.; Lin, J.; Liu, Y.; Li, M.; Chiang, W. Food-Drug Interaction Between the Adlay Bran Oil and Drugs in Rats. Preprints 2019, 2019090104 Yao, H.; Lin, J.; Liu, Y.; Li, M.; Chiang, W. Food-Drug Interaction Between the Adlay Bran Oil and Drugs in Rats. Preprints 2019, 2019090104

Abstract

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) contains various phytonutrients for treating many diseases in Asia. To investigate whether orally administered of adlay bran oil (ABO) can cause drug interactions, the effects of ABO on the pharmacokinetics of five cytochrome P450 (CYP) probe drugs were evaluated. Rats were given a single oral dose (2.5 mL/kg BW) of ABO 1 h before administration of a drug cocktail either orally or intravenously, and blood was collected at various time points. A single oral dose of ABO administration did not affect the pharmacokinetics of five probe drugs when given as a drug cocktail intravenously. However, ABO increased plasma theophylline, dextromethorphan, and diltiazem when co-administered an oral drug cocktail. After 7-days of feeding with an ABO-containing diet, plasma concentrations of theophylline and chlorzoxazone were increased after oral administration of drug cocktail. The major CYP enzyme activities in liver and intestinal were not affected by ABO treatment. Results from this study indicate that a single oral dose or short-term administration of ABO may increase plasma drug concentrations when ABO is given concomitantly with drugs. ABO is likely to enhance intestinal drug absorption. Therefore, caution is needed to avoid food-drug interactions between ABO and co-administered drugs.

Subject Areas

adlay; adlay bran oil; cytochrome P450; food-drug interactions; rats

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