Article
Version 1
This version is not peer-reviewed
Food-Drug Interaction Between the Adlay Bran Oil and Drugs in Rats
Version 1
: Received: 8 September 2019 / Approved: 10 September 2019 / Online: 10 September 2019 (03:16:30 CEST)
How to cite: Yao, H.; Lin, J.; Liu, Y.; Li, M.; Chiang, W. Food-Drug Interaction Between the Adlay Bran Oil and Drugs in Rats. Preprints 2019, 2019090104 Yao, H.; Lin, J.; Liu, Y.; Li, M.; Chiang, W. Food-Drug Interaction Between the Adlay Bran Oil and Drugs in Rats. Preprints 2019, 2019090104
Abstract
Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) contains various phytonutrients for treating many diseases in Asia. To investigate whether orally administered of adlay bran oil (ABO) can cause drug interactions, the effects of ABO on the pharmacokinetics of five cytochrome P450 (CYP) probe drugs were evaluated. Rats were given a single oral dose (2.5 mL/kg BW) of ABO 1 h before administration of a drug cocktail either orally or intravenously, and blood was collected at various time points. A single oral dose of ABO administration did not affect the pharmacokinetics of five probe drugs when given as a drug cocktail intravenously. However, ABO increased plasma theophylline, dextromethorphan, and diltiazem when co-administered an oral drug cocktail. After 7-days of feeding with an ABO-containing diet, plasma concentrations of theophylline and chlorzoxazone were increased after oral administration of drug cocktail. The major CYP enzyme activities in liver and intestinal were not affected by ABO treatment. Results from this study indicate that a single oral dose or short-term administration of ABO may increase plasma drug concentrations when ABO is given concomitantly with drugs. ABO is likely to enhance intestinal drug absorption. Therefore, caution is needed to avoid food-drug interactions between ABO and co-administered drugs.
Keywords
adlay; adlay bran oil; cytochrome P450; food-drug interactions; rats
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
