Preprint Review Version 1 This version is not peer-reviewed

Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease)

Version 1 : Received: 5 September 2019 / Approved: 7 September 2019 / Online: 7 September 2019 (00:31:05 CEST)

How to cite: Peyvandi, H.; Dash, B.C.; Ndon, S.U.; Gabrick, K.S.; Alipour, A..A.; Persing, J.A.; Hsia, H.C. Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease). Preprints 2019, 2019090079 (doi: 10.20944/preprints201909.0079.v1). Peyvandi, H.; Dash, B.C.; Ndon, S.U.; Gabrick, K.S.; Alipour, A..A.; Persing, J.A.; Hsia, H.C. Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease). Preprints 2019, 2019090079 (doi: 10.20944/preprints201909.0079.v1).

Abstract

Buerger's disease or Thromboangiitis Obliterans (TAO) is a nonatherosclerotic segmental vascular disease which affects small and medium arteries and veins in the upper and lower extremities. Based on pathological findings, TAO can be considered as a distinct form of vasculitis that is most prevalent in young male smokers. There is no definitive cure for this disease as therapeutic modalities are limited in number and efficacy. Surgical bypass has limited utility and 24% of patients will ultimately require amputation. Recently, studies have shown that therapeutic angiogenesis and immunomodulatory approaches through the delivery of cells to target tissues are potential options for ischemic lesion treatment. In this review, we summarize the current knowledge of TAO treatment and provide an overview of stem cell-based treatment modalities.

Subject Areas

Thromboangiitis Obliterans; inflammation; angiogenesis; immunomodulation; pluripotent stem cell; mesenchymal stem cell

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