Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease)

Hassan Peyvandi
,
Biraja C. Dash
ORCID logo ,
Sifon U. Ndon
,
Kyle Steven Gabrick
,
Athena Alipour Alipour
,
John A. Persing
,
Henry C. Hsia
*
Version 1 : Received: 5 September 2019 / Approved: 7 September 2019 / Online: 7 September 2019 (00:31:05 CEST)

How to cite: Peyvandi, H.; Dash, B.C.; Ndon, S.U.; Gabrick, K.S.; Alipour, A..A.; Persing, J.A.; Hsia, H.C. Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease). Preprints 2019, 2019090079. https://doi.org/10.20944/preprints201909.0079.v1 Peyvandi, H.; Dash, B.C.; Ndon, S.U.; Gabrick, K.S.; Alipour, A..A.; Persing, J.A.; Hsia, H.C. Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease). Preprints 2019, 2019090079. https://doi.org/10.20944/preprints201909.0079.v1

Abstract

Buerger's disease or Thromboangiitis Obliterans (TAO) is a nonatherosclerotic segmental vascular disease which affects small and medium arteries and veins in the upper and lower extremities. Based on pathological findings, TAO can be considered as a distinct form of vasculitis that is most prevalent in young male smokers. There is no definitive cure for this disease as therapeutic modalities are limited in number and efficacy. Surgical bypass has limited utility and 24% of patients will ultimately require amputation. Recently, studies have shown that therapeutic angiogenesis and immunomodulatory approaches through the delivery of cells to target tissues are potential options for ischemic lesion treatment. In this review, we summarize the current knowledge of TAO treatment and provide an overview of stem cell-based treatment modalities.

Keywords

Thromboangiitis Obliterans; inflammation; angiogenesis; immunomodulation; pluripotent stem cell; mesenchymal stem cell

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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