Perspectives on the Use of Hyaluronidase from the Red King Crab Hepatopancreas in Treating Filler Complications: In Vitro Investigations

Tatyana Ponomareva; Dmitrii Sliadovskii; Maria Timchenko; Alexander Timchenko; Evgeny Sogorin

doi:10.20944/preprints201909.0001.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 30 August 2019 / Approved: 1 September 2019 / Online: 1 September 2019 (02:31:34 CEST)
Version 2 : Received: 14 October 2019 / Approved: 14 October 2019 / Online: 14 October 2019 (15:42:23 CEST)

The kinetics of the hydrolysis of hyaluronic acid (HA) of cosmetic fillers using thehomogenate of the red king crab hepatopancreas was studied for the first time. Turbidimetricanalysis of the reaction mixture revealed a bell–shaped time dependence of aggregation formation. The HA fillers were examined by atomic force microscopy (AFM) and it was found that they wererepresented by spherical–like structures. These structures were disrupted under the action of thehomogenate of the red king crab hepatopancreas. It was shown that the prepared homogenate hasthe activity which is similar to that observed in the commercially available hyaluronidase products.The preparation with hyaluronidase activity obtained from the red king crab hepatopancreas couldbe used as potentially safe product for treating filler complications.

treating filler complications; hyaluronidase; red king crab; hepatopancreas; hyaluronic acid (HA); hyaluronidase activity; turbidimetric method; atomic force microscopy (AFM); Revofil Ultra filler; Hyaluform deep filler; Lydase; Liporase

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Perspectives on the Use of Hyaluronidase from the Red King Crab Hepatopancreas in Treating Filler Complications: In Vitro Investigations

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