Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity

Version 1 : Received: 27 August 2019 / Approved: 28 August 2019 / Online: 28 August 2019 (14:51:29 CEST)

How to cite: Nowicki, G.J.; Ślusarska, B.; Prystupa, A.; Polak, M.; Czubaj-Kowal, M.; Rudnicka-Drożak, E. Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity. Preprints 2019, 2019080297. https://doi.org/10.20944/preprints201908.0297.v1 Nowicki, G.J.; Ślusarska, B.; Prystupa, A.; Polak, M.; Czubaj-Kowal, M.; Rudnicka-Drożak, E. Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity. Preprints 2019, 2019080297. https://doi.org/10.20944/preprints201908.0297.v1

Abstract

Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress level. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). OxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the studied groups. Significant positive correlation between PerOx and percentage of adipose tissue (FM [%]) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with VAI in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAI of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.

Keywords

oxidative status; antioxidant status; oxidative stress; cardiovascular diseases; overweight; obesity

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

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