Version 1
: Received: 24 August 2019 / Approved: 25 August 2019 / Online: 25 August 2019 (17:01:23 CEST)
How to cite:
Li, Z.; Ding, X.; Song, H. Research Progress of circRNA in Epithelial Mesenchymal Transformation of Gastric Cancer. Preprints2019, 2019080258. https://doi.org/10.20944/preprints201908.0258.v1
Li, Z.; Ding, X.; Song, H. Research Progress of circRNA in Epithelial Mesenchymal Transformation of Gastric Cancer. Preprints 2019, 2019080258. https://doi.org/10.20944/preprints201908.0258.v1
Li, Z.; Ding, X.; Song, H. Research Progress of circRNA in Epithelial Mesenchymal Transformation of Gastric Cancer. Preprints2019, 2019080258. https://doi.org/10.20944/preprints201908.0258.v1
APA Style
Li, Z., Ding, X., & Song, H. (2019). Research Progress of circRNA in Epithelial Mesenchymal Transformation of Gastric Cancer. Preprints. https://doi.org/10.20944/preprints201908.0258.v1
Chicago/Turabian Style
Li, Z., Xiaoyun Ding and Haojun Song. 2019 "Research Progress of circRNA in Epithelial Mesenchymal Transformation of Gastric Cancer" Preprints. https://doi.org/10.20944/preprints201908.0258.v1
Abstract
With the continuous progress in modern medicine, the early detection rate of gastric cancer has increased, and the mortality rate has decreased. However, gastric cancer remains the third leading cause of cancer-related death worldwide, with a high recurrence rate. Metastasis is the leading cause of death and recurrence of gastric cancer, which greatly hinders treatment success. Cancer development is a complex process involving multiple sequential steps. In the metastatic cascade, local invasion may be considered an initial, crucial step in the development of a malignant tumor, which leads to distant metastasis. Epithelial-mesenchymal transformation (EMT) is one of the most important developmental processes that occur during tumor invasion. EMT confers certain basic abilities to cancer cells, such as migration, invasion and anti-apoptotic ability, thus initiating and increasing metastasis. However, little is known about the molecular mechanisms that promote EMT and gastric cancer cell metastasis. A number of recent studies have found that circular RNAs（circRNAs）are associated with gastric cancer EMT, regulating the EMT process and promoting the occurrence and development of tumors. Because of their unique continuous circular structure, circRNAs have relatively high stability in plasma and cells, making them more suitable as diagnostic biomarkers in malignant tumors. Therefore, understanding the mechanism of circRNAs in EMT in gastric cancer is an important research direction to actively prevent tumor metastasis and improve the therapeutic effect on advanced malignant tumors.
Keywords
circRNAs; gastric cancer; EMT
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
