Version 1
: Received: 21 August 2019 / Approved: 22 August 2019 / Online: 22 August 2019 (03:58:59 CEST)
How to cite:
Monaco, A.; Ovryn, B.; Axis, J.; Amsler, K. The Leak Pathway: A Pathway in Flux. Preprints2019, 2019080229. https://doi.org/10.20944/preprints201908.0229.v1
Monaco, A.; Ovryn, B.; Axis, J.; Amsler, K. The Leak Pathway: A Pathway in Flux. Preprints 2019, 2019080229. https://doi.org/10.20944/preprints201908.0229.v1
Monaco, A.; Ovryn, B.; Axis, J.; Amsler, K. The Leak Pathway: A Pathway in Flux. Preprints2019, 2019080229. https://doi.org/10.20944/preprints201908.0229.v1
APA Style
Monaco, A., Ovryn, B., Axis, J., & Amsler, K. (2019). The Leak Pathway: A Pathway in Flux. Preprints. https://doi.org/10.20944/preprints201908.0229.v1
Chicago/Turabian Style
Monaco, A., Josephine Axis and Kurt Amsler. 2019 "The Leak Pathway: A Pathway in Flux" Preprints. https://doi.org/10.20944/preprints201908.0229.v1
Abstract
The epithelial cell tight junction structure is the site of the transepithelial movement of solutes and water between epithelial cells (paracellular permeability). Paracellular permeability can be divided into two distinct pathways, the Pore Pathway mediating the movement of small ions and solutes and the Leak Pathway mediating the movement of large solutes. Claudin proteins form the basic paracellular permeability barrier and mediate the movement of small ions and solutes via the Pore Pathway. The Leak Pathway remains less understood. Several proteins have been implicated in mediating the Leak Pathway, including occludin, ZO proteins, tricellulin, and actin filaments, but the proteins comprising the Leak Pathway remain unresolved. The properties of the Leak Pathway, such as its molecular mechanism, its regulation, and whether or not it has a size limit, remain controversial. This review will trace the evolution of the Leak Pathway concept from its origins, will discuss the current information about the properties of the Leak Pathway, and will discuss recent research suggesting a possible molecular basis for the Leak Pathway. Based on these findings, we propose a model for the molecular mechanism underlying the Leak Pathway and its regulation.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
