Preprint Review Version 1 This version is not peer-reviewed

Structure and Function of Multimeric G-quadruplexes

Version 1 : Received: 15 August 2019 / Approved: 16 August 2019 / Online: 16 August 2019 (07:57:25 CEST)

A peer-reviewed article of this Preprint also exists.

Kolesnikova, S.; Curtis, E.A. Structure and Function of Multimeric G-Quadruplexes. Molecules 2019, 24, 3074. Kolesnikova, S.; Curtis, E.A. Structure and Function of Multimeric G-Quadruplexes. Molecules 2019, 24, 3074.

Journal reference: Molecules 2019, 24, 3074
DOI: 10.3390/molecules24173074

Abstract

G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles. G-quadruplexes are often studied as monomers but can also form a variety of higher-order structures. This increases the structural and functional diversity of G-quadruplexes, and recent evidence suggests that it could also be biologically important. In this review we describe the types of multimeric topologies adopted by G-quadruplexes and highlight what is known about their sequence requirements. We also summarize the limited information available about potential biological roles of multimeric G-quadruplexes and suggest new approaches that could facilitate future studies of these structures.

Subject Areas

G-quadruplex; dimer; tetramer; multimer; oligomer; telomere; promoter; R-loop; DNA:RNA hybrid

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