Preprint Article Version 1 This version is not peer-reviewed

Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats

Version 1 : Received: 13 July 2019 / Approved: 15 July 2019 / Online: 15 July 2019 (05:59:18 CEST)

How to cite: Sari, D.K.; Marianne, M.; Lestari, S.; Laksmi, L.I. Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats. Preprints 2019, 2019070179 (doi: 10.20944/preprints201907.0179.v1). Sari, D.K.; Marianne, M.; Lestari, S.; Laksmi, L.I. Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats. Preprints 2019, 2019070179 (doi: 10.20944/preprints201907.0179.v1).

Abstract

High oxidative stress in cells due to inflammation process or excessive cell proliferation would produce oxidants or free radicals with biomarkers, one of which is malondialdehyde (MDA). Passion fruit seed’s contain high antioxidant and are expected to decrease the level of cholesterol and MDA. The objective is to identify the effect of passion fruit seed’s ethanol extract in Wistar rats that have been fed with atherogenic feed. The method was preclinical trial (post-test control group design) in rats, by administering passion fruit seed’s ethanol extract for 14 days. This study used 26 male rats aged two months, divided into 5 groups. The result showed significant difference in MDA level which was found in group that was given passion fruit seed extract 10mg/kg BW with positive control group that was given standard feed. Passion fruit seed’s extract showed significant difference in level of triglyceride, which was found in negative control group that was given atherogenic feed with group that was given passion fruit seed’s extract 5mg/kg BW (mean±standard deviation: 1.09±0.30 mg/dL vs 0.77±0.25mg/dL; p=0.048). This study showed that passion fruit seed’s ethanol extract had significant lowering effect in level of MDA, total cholesterol, and triglyceride for 14 days.

Subject Areas

atherogenesis; passiflora edulis sims; lipid profile; free radicals; pre-clinical trial

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