PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats
Version 1
: Received: 13 July 2019 / Approved: 15 July 2019 / Online: 15 July 2019 (05:59:18 CEST)
How to cite:
Sari, D. K.; Marianne, M.; Lestari, S.; Laksmi, L. I. Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats. Preprints2019, 2019070179. https://doi.org/10.20944/preprints201907.0179.v1
Sari, D. K.; Marianne, M.; Lestari, S.; Laksmi, L. I. Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats. Preprints 2019, 2019070179. https://doi.org/10.20944/preprints201907.0179.v1
Sari, D. K.; Marianne, M.; Lestari, S.; Laksmi, L. I. Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats. Preprints2019, 2019070179. https://doi.org/10.20944/preprints201907.0179.v1
APA Style
Sari, D. K., Marianne, M., Lestari, S., & Laksmi, L. I. (2019). Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats. Preprints. https://doi.org/10.20944/preprints201907.0179.v1
Chicago/Turabian Style
Sari, D. K., Sri Lestari and Lidya Imelda Laksmi. 2019 "Difference in Level of Malondialdehyde, Total Cholesterol, and Triglyceride After Administration of Passion Fruit Seed’s Ethanol Extract in Wistar Rats" Preprints. https://doi.org/10.20944/preprints201907.0179.v1
Abstract
High oxidative stress in cells due to inflammation process or excessive cell proliferation would produce oxidants or free radicals with biomarkers, one of which is malondialdehyde (MDA). Passion fruit seed’s contain high antioxidant and are expected to decrease the level of cholesterol and MDA. The objective is to identify the effect of passion fruit seed’s ethanol extract in Wistar rats that have been fed with atherogenic feed. The method was preclinical trial (post-test control group design) in rats, by administering passion fruit seed’s ethanol extract for 14 days. This study used 26 male rats aged two months, divided into 5 groups. The result showed significant difference in MDA level which was found in group that was given passion fruit seed extract 10mg/kg BW with positive control group that was given standard feed. Passion fruit seed’s extract showed significant difference in level of triglyceride, which was found in negative control group that was given atherogenic feed with group that was given passion fruit seed’s extract 5mg/kg BW (mean±standard deviation: 1.09±0.30 mg/dL vs 0.77±0.25mg/dL; p=0.048). This study showed that passion fruit seed’s ethanol extract had significant lowering effect in level of MDA, total cholesterol, and triglyceride for 14 days.
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
