Preprint Review Version 2 This version is not peer-reviewed

Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products

Version 1 : Received: 1 July 2019 / Approved: 2 July 2019 / Online: 2 July 2019 (11:30:34 CEST)
Version 2 : Received: 22 July 2019 / Approved: 23 July 2019 / Online: 23 July 2019 (10:30:06 CEST)

How to cite: Ahmad, B.; Serpell, C.; Lim, I.F.; Wong, E.H. Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products. Preprints 2019, 2019070040 (doi: 10.20944/preprints201907.0040.v2). Ahmad, B.; Serpell, C.; Lim, I.F.; Wong, E.H. Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products. Preprints 2019, 2019070040 (doi: 10.20944/preprints201907.0040.v2).

Abstract

The Abnormal increase in the mass of adipose tissue during adipogenesis results in obesity. Obesity is a predominant disorder and its widespread has become a critical concern worldwide. This is due to the burden of its associated co-morbidities like cancer, cardiovascular diseases and diabetes. Over-nutrition and the sedentary lifestyle are considered as the most significant causes of abnormal adipose tissue development. Appropriate lifestyle and behavioural interventions are the corner stones of successful weight loss, but to maintain such a lifestyle is highly challenging. Accordingly, natural products from plants either as crude extracts or purified phytochemicals have shown to have anti-obesogenic properties and are generally non-toxic and cost-effective. In this review, we discuss the comparative analysis of molecular mechanisms involved in adipogenesis and the recently reported anti-obesogenic effects of various plant products. We will provide a common platform for understanding obesity and adipogenesis, and a possible mechanism of action for anti-obesogenic plant products through AMP-activated protein kinase (AMPK), which will support the scientific development of traditional herbal medicine.

Subject Areas

adipogenesis; AMPK; plant products; anti-obesogenic; beige/brite adipocytes; natural products; phytochemicals

Comments (1)

Comment 1
Received: 23 July 2019
Commenter: ENG HWA WONG
Commenter's Conflict of Interests: Author
Comment: The title of the manuscript is changed. The abstract, contents in Table 2, and 3 were modified. New figures 3 and 4 were added.
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