Preprint Review Version 1 This version is not peer-reviewed

Lytic Bacteriophages and Phage Cocktails Seem to be a Future Alternative Against Multi-Drug Resistant Bacterial Infections

Version 1 : Received: 7 June 2019 / Approved: 11 June 2019 / Online: 11 June 2019 (10:08:07 CEST)

How to cite: Pallavali, R.R.; Degati, V.L.; Durbaka, V.R.P. Lytic Bacteriophages and Phage Cocktails Seem to be a Future Alternative Against Multi-Drug Resistant Bacterial Infections. Preprints 2019, 2019060094 (doi: 10.20944/preprints201906.0094.v1). Pallavali, R.R.; Degati, V.L.; Durbaka, V.R.P. Lytic Bacteriophages and Phage Cocktails Seem to be a Future Alternative Against Multi-Drug Resistant Bacterial Infections. Preprints 2019, 2019060094 (doi: 10.20944/preprints201906.0094.v1).

Abstract

Lytic bacteriophages have the efficacy to act and eradicate pathogenic bacteria as an attractive tool in the near future. Bacteriophages specifically kill multidrug-resistant bacteria even which have the capacity to form biofilms. The present review mainly focused on the efficacy of bacteriophages and cocktails as therapeutic agents against predominate MDR-bacteria and their biofilms which are isolated from septic wound infections. The body of evidence includes data from studies investigating bacteriophages from sewage samples as novel antibacterial and antibiofilm agents against pathogenic bacteria. The goal of this review is to present an overview on predominant bacteria from septic wound infection, the biofilm-forming capacity of bacteria, lytic effect of bacteriophages and phage cocktails with an emphasis on the application of bacteriophages against septic wound causing bacteria.

Subject Areas

Bacteriophages, Septic wound infection, MDR, Biofilms, Phage Cocktails

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