Working Paper Review Version 2 This version is not peer-reviewed

Neuropsin in Mental Health

Version 1 : Received: 29 May 2019 / Approved: 29 May 2019 / Online: 29 May 2019 (16:50:08 CEST)
Version 2 : Received: 23 December 2019 / Approved: 24 December 2019 / Online: 24 December 2019 (08:53:38 CET)

How to cite: Bukowski, L.; Chernomorchenko, A.; Starnawska, A.; Mors, O.; Staunstrup, N.H.; Børglum, A.D.; Qvist, P. Neuropsin in Mental Health. Preprints 2019, 2019050360 Bukowski, L.; Chernomorchenko, A.; Starnawska, A.; Mors, O.; Staunstrup, N.H.; Børglum, A.D.; Qvist, P. Neuropsin in Mental Health. Preprints 2019, 2019050360

Abstract

Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic proteins. Its substrates comprise several molecules central to structural synaptic plasticity, and studies in rodents have documented its role in cognition and the behavioral and neurobiological response to stress. Intriguingly, differential usage of KLK8 (neuropsin gene) splice forms in the fetal and adult brain has only been reported in humans, suggesting that neuropsin may serve a specialized role in human neurodevelopment. Through systematic interrogation of large-scale genetic data, we review KLK8 regulation in the context of mental health and provide a summary of clinical and preclinical evidence supporting a role for neuropsin in the pathogenesis of mental illness.

Subject Areas

neuropsin; KLK8; mental disorders; mental health

Comments (1)

Comment 1
Received: 24 December 2019
Commenter: Lina Bukowski
Commenter's Conflict of Interests: Author
Comment: The updated version of our review inludes a re-analysis of data from the most comprehensive human brain single cell studies assessing KLK8 expression in several brain tissues and developmental stages, as well as a screening of KLK8 expression data from RNA sequencing expression experiments on post-mortem brain tissues from MDD, BD and SZ patients.
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