Preprint Article Version 1 This version is not peer-reviewed

Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology

Version 1 : Received: 16 May 2019 / Approved: 17 May 2019 / Online: 17 May 2019 (16:15:53 CEST)

How to cite: Bailey, P.; Martin, S.S. Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology. Preprints 2019, 2019050226 (doi: 10.20944/preprints201905.0226.v1). Bailey, P.; Martin, S.S. Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology. Preprints 2019, 2019050226 (doi: 10.20944/preprints201905.0226.v1).

Abstract

Circulating tumor cells (CTC) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in prognosis of patient outcomes. The presence of circulating tumor materials (CTMat) can advertise the presence of metastasis before clinical presentation, enabling early detection of relapse. Importantly, emerging evidence is indicating that cancer treatments can actually increase the incidence of CTCs and metastasis in pre-clinical models. Subsequently, the study of CTCs, their biology and function are of vital importance. Emerging technologies for the capture of CTC/CTMs and CTMat are elucidating vitally important biological and functional information that can lead to important alterations in how therapies are administered. This paves the way for the development of a “liquid biopsy” where treatment decisions can be informed by information gleaned from tumor cells and tumor cell debris in the blood.

Subject Areas

Circulating Tumor Cells; CTC; Liquid Biopsy; CTM; CTMat; CTC Biology; CTC Capture Technology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.