Vasilev, H.; Ross, S.; Šmejkal, K.; Maršík, P.; Jankovská, D.; Havlík, J.; Veselý, O. Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.). Molecules2019, 24, 1419.
Vasilev, H.; Ross, S.; Šmejkal, K.; Maršík, P.; Jankovská, D.; Havlík, J.; Veselý, O. Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.). Molecules 2019, 24, 1419.
Astragalus is a very interesting plant genus well-known for content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing a number of activities, like immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic A. aitosensis (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of A. aitosensis extract to obtain seven phenolic compounds (1–7), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analysis and HR-MS allowed us to resolve the structures of known compounds 5–7 as isorhamnetin-3-O-robinobioside, isorhamnetin-3-O-(2,6-di-O-α-rhamno-pyranosyl-β-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides 1–4. These were described in plant source for the first time.
Astragalus aitosensis; flavonoid; glycoside
CHEMISTRY, Medicinal Chemistry
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