Preprint Review Version 1 This version is not peer-reviewed

Phytochemical Constituents and Pharmacological Activities of Picrasma javanica

Version 1 : Received: 18 March 2019 / Approved: 19 March 2019 / Online: 19 March 2019 (10:49:34 CET)

How to cite: Taher, M.; Mohd Razali, N.F.; Susanti, D.; Zakaria, Z.A. Phytochemical Constituents and Pharmacological Activities of Picrasma javanica. Preprints 2019, 2019030185 Taher, M.; Mohd Razali, N.F.; Susanti, D.; Zakaria, Z.A. Phytochemical Constituents and Pharmacological Activities of Picrasma javanica. Preprints 2019, 2019030185

Abstract

Picrasma javanica Blume or also known as Picrasma nepalensis or Picrasma philippinensis is a plant belongs to the Simaroubaceae family, which is known for its secondary metabolites namely quassinoids with various pharmacological properties including antitumor, antimalarial and antiviral. The plant traditionally used as medicine for different diseases in Myanmar, Thailand and Indonesia. The purpose of this study is to discern the phytochemical constituents and pharmacological activities of Picrasma javanica. The background, phytochemical constituents and pharmacological benefits of Picrasma javanica were reviewed and supported from previous studies, including in vivo and in vitro studies. The literature used in the review comprises of published books, journals, reviews and articles published from the year of 1969 to 2018, which are available in ScienceDirect, PubMed, Scopus and GoogleScholar. Chemical structures presented in this paper are either drawn with ACD/ChemSketch. Picrasma javanica possesses several phytochemical constituents, including quassinoids, alkaloids and triterpenoids. Compounds of the plant were isolated and studied for their pharmacological activities such as antimalarial, antiproliferative, antiviral, antimicrobial and membrane stabilising activity. Most importantly, these studies showed that the key players for the pharmacological benefits are quassinoids and alkaloids present in the plant.Picrasma javanica indeed has therapeutic potentials which may be beneficial for people. However, further extensive studies must be done on the plant as the detailed information on its pharmacological activities are still lacking.

Subject Areas

Simaroubaceae; Picrasma javanica; quassionoids; phytochemicals; pharmacological properties

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