Preprint Review Version 1 This version is not peer-reviewed

MAPK/ERK Signaling in Renal Differentiation

Version 1 : Received: 11 March 2019 / Approved: 13 March 2019 / Online: 13 March 2019 (09:00:32 CET)

How to cite: Kurtzeborn, K.; Kwon, H.N.; Kuure, S. MAPK/ERK Signaling in Renal Differentiation. Preprints 2019, 2019030138 (doi: 10.20944/preprints201903.0138.v1). Kurtzeborn, K.; Kwon, H.N.; Kuure, S. MAPK/ERK Signaling in Renal Differentiation. Preprints 2019, 2019030138 (doi: 10.20944/preprints201903.0138.v1).

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects deriving from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how MAPK/ERK activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Recent studies also demonstrate that MAPK/ERK pathway is directly involved in nephrogenesis, regulating both the maintenance and differentiation of the nephrogenic mesenchyme. Interestingly, aberrant MAPK/ERK signaling is linked to many cancers, and recent studies suggest it also plays a role in the most common pediatric renal cancer, Wilms’ tumor.

Subject Areas

extracellular signal-regulated kinase; MAPK/ERK signaling; intracellular signaling; kidney development; ureteric bud branching morphogenesis; nephrogenesis; progenitor cells; self-renewal; differentiation

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