Version 1
: Received: 18 February 2019 / Approved: 19 February 2019 / Online: 19 February 2019 (11:14:48 CET)
How to cite:
Yamaguchi, T.; Dijkstra, J.M. Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish. Preprints2019, 2019020179. https://doi.org/10.20944/preprints201902.0179.v1
Yamaguchi, T.; Dijkstra, J.M. Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish. Preprints 2019, 2019020179. https://doi.org/10.20944/preprints201902.0179.v1
Yamaguchi, T.; Dijkstra, J.M. Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish. Preprints2019, 2019020179. https://doi.org/10.20944/preprints201902.0179.v1
APA Style
Yamaguchi, T., & Dijkstra, J.M. (2019). Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish. Preprints. https://doi.org/10.20944/preprints201902.0179.v1
Chicago/Turabian Style
Yamaguchi, T. and Johannes M. Dijkstra. 2019 "Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish" Preprints. https://doi.org/10.20944/preprints201902.0179.v1
Abstract
The basic pattern of MHC variation in fish, with MHC class I versus class II, and polymorphic classical versus nonpolymorphic nonclassical, is similar in fish and mammals. Nevertheless, in many or all teleost fishes, important differences with mammalian or human MHC were observed: (1) The allelic/haplotype diversification levels of classical MHC class I genes tend to be much higher than in mammals; (2) Teleost fish classical MHC class I and class II loci are not linked. The present article summarizes previous studies that performed quantitative trait loci (QTL) analysis for mapping differences in teleost fish disease resistance, and discusses them from MHC point of view. Overall, those studies suggest the possible importance of genomic regions including classical MHC class II and nonclassical MHC class I genes, whereas similar observations were not made for the genomic regions with the highly diversified classical MHC class I alleles. The present study is a review and discussion of the fish MHC situation.
Keywords
Histocompatibility complex (MHC) genes, disease resistance, fish
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
