Preprint Review Version 1 This version is not peer-reviewed

Gene therapy approaches to functional cure and protection of hematopoietic potential in HIV infection

Version 1 : Received: 7 February 2019 / Approved: 8 February 2019 / Online: 8 February 2019 (09:31:14 CET)

A peer-reviewed article of this Preprint also exists.

Tsukamoto, T. Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection. Pharmaceutics 2019, 11, 114. Tsukamoto, T. Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection. Pharmaceutics 2019, 11, 114.

Journal reference: Pharmaceutics 2019, 11, 114
DOI: 10.3390/pharmaceutics11030114

Abstract

Although current antiretroviral drug therapy can suppress human immunodeficiency virus (HIV) replication, a lifelong prescription is necessary to avoid viral rebound. The problem of persistent and ineradicable viral reservoirs in HIV-infected people continues to be a global threat. In addition, some HIV-infected patients do not experience sufficient T-cell immune restoration despite being aviremic during treatment, and this is likely due to altered hematopoietic potential. To achieve global eradication of HIV disease, a cure is needed. To this end, tremendous efforts have been made in the field of anti-HIV gene therapy. This review will discuss the concepts of HIV cure and relative viral attenuation and provide an overview of various gene therapy approaches aimed at a complete or functional HIV cure and protection of hematopoietic functions.

Subject Areas

human immunodeficiency virus; acquired immunodeficiency syndrome; hematopoietic stem/progenitor cells; gene therapy

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