Preprint Review Version 1 This version is not peer-reviewed

Gene therapy approaches to functional cure and protection of hematopoietic potential in HIV infection

Version 1 : Received: 7 February 2019 / Approved: 8 February 2019 / Online: 8 February 2019 (09:31:14 CET)

How to cite: Tsukamoto, T. Gene therapy approaches to functional cure and protection of hematopoietic potential in HIV infection. Preprints 2019, 2019020079 (doi: 10.20944/preprints201902.0079.v1). Tsukamoto, T. Gene therapy approaches to functional cure and protection of hematopoietic potential in HIV infection. Preprints 2019, 2019020079 (doi: 10.20944/preprints201902.0079.v1).

Abstract

Although current antiretroviral drug therapy can suppress human immunodeficiency virus (HIV) replication, a lifelong prescription is necessary to avoid viral rebound. The problem of persistent and ineradicable viral reservoirs in HIV-infected people continues to be a global threat. In addition, some HIV-infected patients do not experience sufficient T-cell immune restoration despite being aviremic during treatment, and this is likely due to altered hematopoietic potential. To achieve global eradication of HIV disease, a cure is needed. To this end, tremendous efforts have been made in the field of anti-HIV gene therapy. This review will discuss the concepts of HIV cure and relative viral attenuation and provide an overview of various gene therapy approaches aimed at a complete or functional HIV cure and protection of hematopoietic functions.

Subject Areas

human immunodeficiency virus; acquired immunodeficiency syndrome; hematopoietic stem/progenitor cells; gene therapy

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