Preprint Hypothesis Version 1 This version is not peer-reviewed

Cell Sheets: From Delivery Tool to a Model of Guided Regeneration

Version 1 : Received: 18 December 2018 / Approved: 19 December 2018 / Online: 19 December 2018 (16:22:42 CET)

How to cite: Nimiritsky, P.; Eremichev, R.; Alexandrushkina, N.; Efimenko, A.; Tkachuk, V.; Makarevich, P. Cell Sheets: From Delivery Tool to a Model of Guided Regeneration. Preprints 2018, 2018120238 (doi: 10.20944/preprints201812.0238.v1). Nimiritsky, P.; Eremichev, R.; Alexandrushkina, N.; Efimenko, A.; Tkachuk, V.; Makarevich, P. Cell Sheets: From Delivery Tool to a Model of Guided Regeneration. Preprints 2018, 2018120238 (doi: 10.20944/preprints201812.0238.v1).

Abstract

Regeneration is a fundamental perpetual tissue process much attributed to functions of adult stem cell. In last decades delivery of adult stem cells to restore tissue structure is widely adopted in regenerative medicine. However, delivery of stem cells can not complete the task of human body regeneration effectively as far as cells need a basis to form a tissue. Certain improvement can be achieved when cells are organized to cells sheets (CS) – primitive tissue-engineered structures comprising of viable cells and ECM proteins. This led us to an assumption that after damage an intermediate feeder is structure formed as a ground for future tissue resulting in gradients of stimuli required to attract other cells (vascular, neural, epithelial, parenchyma etc.) in an organized manner. This feeder acquires increasing heterogeneity and becomes a guiding feeder that provides basic level of organization to increase complexity of structure up to normal tissue. We also highlight potential role of adult mesenchymal stromal cells (MSC) as the main source of guiding feeder and support it by our recent knowledge of their biological function. Finally, we assume that CS known to be a feasible delivery tool in therapeutics resemble guiding feeder and show our own data indicating properties of MSC-based CS. Furthermore, this concept shifts our understanding of therapeutic mechanism underlying a widely known delivery method for regenerative medicine.

Subject Areas

stem cell, stromal cell, mesenchymal stromal cell, regeneration, histogenesis, cell sheet, cell delivery

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