Preprint Review Version 1 This version is not peer-reviewed

Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

Version 1 : Received: 29 November 2018 / Approved: 3 December 2018 / Online: 3 December 2018 (09:06:22 CET)

A peer-reviewed article of this Preprint also exists.

Shrestha, S.; Hazelbaker, M.; Yount, A.L.; Walczak, C.E. Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation. Biomolecules 2019, 9, 1. Shrestha, S.; Hazelbaker, M.; Yount, A.L.; Walczak, C.E. Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation. Biomolecules 2019, 9, 1.

Journal reference: Biomolecules 2018, 9, 1
DOI: 10.3390/biom9010001

Abstract

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

Subject Areas

microtubule dynamics; mitosis; spindle; molecular motor protein

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