Niiyam, E.; Tanabe, K.; Uto, K.; Kikuchi, A.; Ebara, M. Shape-memory Nanofiber Meshes with Programmable Cell Orientation. Preprints2018, 2018110585. https://doi.org/10.20944/preprints201811.0585.v1
APA Style
Niiyam, E., Tanabe, K., Uto, K., Kikuchi, A., & Ebara, M. (2018). Shape-memory Nanofiber Meshes with Programmable Cell Orientation. Preprints. https://doi.org/10.20944/preprints201811.0585.v1
Chicago/Turabian Style
Niiyam, E., Akihiko Kikuchi and Mitsuhiro Ebara. 2018 "Shape-memory Nanofiber Meshes with Programmable Cell Orientation" Preprints. https://doi.org/10.20944/preprints201811.0585.v1
Abstract
This paper reports a rational design of temperature-responsive nanofiber meshes with shape-memory effect. The meshes were fabricated by electrospinning a poly(ε-caprolactone) (PCL)-based polyurethane with different contents of soft and hard segments. The effects of PCL diol/hexamethylene diisocyanate (HDI)/1,4-butanediol (BD) molar ratio in terms of the contents of soft and hard segments on the shape-memory properties were investigated. Although the mechanical property improved with increasing hard segment ratio, optimal shape-memory properties were obtained with a PCL/HDI/BD molar ratio of 1:4:3. At a microscopic level, the original nanofibrous structure was easily deformed into a temporary shape, and recovered its original structure when the sample was reheated. A higher recovery rate (>89%) was achieved even when the mesh was deformed up to 400%. Finally, the nanofiber meshes were used to control the alignment of human mesenchymal stem cells (hMSCs). The hMSCs aligned well along the fiber orientation. The proposed nanofibrous meshes with the shape-memory effect have the potential to serve as in vitro platforms for the investigation of cell functions as well as implantable scaffolds for wound-healing applications.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
