Preprint Review Version 1 This version is not peer-reviewed

Chaperoning the Mononegavirales: Current Knowledge and Future Directions

Version 1 : Received: 16 November 2018 / Approved: 19 November 2018 / Online: 19 November 2018 (17:22:51 CET)

A peer-reviewed article of this Preprint also exists.

Latorre, V.; Mattenberger, F.; Geller, R. Chaperoning the Mononegavirales: Current Knowledge and Future Directions. Viruses 2018, 10, 699. Latorre, V.; Mattenberger, F.; Geller, R. Chaperoning the Mononegavirales: Current Knowledge and Future Directions. Viruses 2018, 10, 699.

Journal reference: Viruses 2018, 10, 699
DOI: 10.3390/v10120699

Abstract

The order Mononegavirales harbors numerous viruses of significant relevance for human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses and antiviral therapies remain limited. Being obligate cellular parasites, viruses must utilize the cellular machinery for their replication and spread. Therefore, targeting cellular pathways used by viruses can provide novel therapeutic approaches. One of the key challenges confronted by both hosts and viruses alike is the successful folding and maturation of proteins. In cells, this task is faced by cellular molecular chaperones, a group of conserved and abundant proteins that oversee protein folding and help maintain protein homeostasis. In this review, we summarize the current knowledge of how the mononegavirales interact with cellular chaperones, highlight key gaps in our knowledge, and discuss the potential of chaperone inhibitors as antivirals.

Subject Areas

Mononegavirales; Chaperones; Antivirals; Hsp70; Hsp90; CCT; Respiratory syncytial virus; Measles virus; Mumps Virus; Rabies virus; Ebola virus.

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