Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing

Seweryn Bialasiewicz; Tania P.S. Duarte; Son H. Nguyen; Vichitra Sukumaran; Alexandra Stewart; Sally Appleton; Miranda E. Pitt; Arnold Bainomugisa; Amy V. Jennison; Rikki Graham; Lachlan J.M. Coin; Krispin Hajkowicz

doi:10.20944/preprints201811.0395.v1

How to cite: Bialasiewicz, S.; Duarte, T.P.; Nguyen, S.H.; Sukumaran, V.; Stewart, A.; Appleton, S.; Pitt, M.E.; Bainomugisa, A.; Jennison, A.V.; Graham, R.; Coin, L.J.; Hajkowicz, K. Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing. Preprints 2018, 2018110395 (doi: 10.20944/preprints201811.0395.v1). Bialasiewicz, S.; Duarte, T.P.; Nguyen, S.H.; Sukumaran, V.; Stewart, A.; Appleton, S.; Pitt, M.E.; Bainomugisa, A.; Jennison, A.V.; Graham, R.; Coin, L.J.; Hajkowicz, K. Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing. Preprints 2018, 2018110395 (doi: 10.20944/preprints201811.0395.v1).

Abstract

We present a case of Capnocytophaga canimorsus septic shock after a dog bite in an immunocompetent individual, where real-time nanopore metagenomic sequencing characterized the microbial agent within 19 hours, with subsequent confirmation using droplet digital PCR. Oral swabs from the dog demonstrated a nearly-identical C. canimorsus isolate by sequencing.

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Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing

Abstract

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Subject

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