Preprint Article Version 1 This version is not peer-reviewed

Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing

Version 1 : Received: 14 November 2018 / Approved: 16 November 2018 / Online: 16 November 2018 (09:45:38 CET)

How to cite: Bialasiewicz, S.; Duarte, T.P..; Nguyen, S.H..; Sukumaran, V..; Stewart, A..; Appleton, S..; Pitt, M.E..; Bainomugisa, A..; Jennison, A.V.; Graham, R..; Coin, L.J..; Hajkowicz, K.. Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing. Preprints 2018, 2018110395 (doi: 10.20944/preprints201811.0395.v1). Bialasiewicz, S.; Duarte, T.P..; Nguyen, S.H..; Sukumaran, V..; Stewart, A..; Appleton, S..; Pitt, M.E..; Bainomugisa, A..; Jennison, A.V.; Graham, R..; Coin, L.J..; Hajkowicz, K.. Rapid Diagnosis of Capnocytophaga canimorsus Septic Shock in an Immunocompetent Individual Using Real-Time Nanopore Sequencing. Preprints 2018, 2018110395 (doi: 10.20944/preprints201811.0395.v1).

Abstract

We present a case of Capnocytophaga canimorsus septic shock after a dog bite in an immunocompetent individual, where real-time nanopore metagenomic sequencing characterized the microbial agent within 19 hours, with subsequent confirmation using droplet digital PCR. Oral swabs from the dog demonstrated a nearly-identical C. canimorsus isolate by sequencing.

Subject Areas

nanopore sequencing; droplet digital PCR; Capnocytophaga canimorsus; diagnosis; sepsis

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