Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture

Version 1 : Received: 12 November 2018 / Approved: 14 November 2018 / Online: 14 November 2018 (08:50:01 CET)
Version 2 : Received: 24 January 2019 / Approved: 25 January 2019 / Online: 25 January 2019 (11:36:58 CET)

How to cite: Rubio, N.; Datar, I.; Stachura, D.; Krueger, K. Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture. Preprints 2018, 2018110326. https://doi.org/10.20944/preprints201811.0326.v1 Rubio, N.; Datar, I.; Stachura, D.; Krueger, K. Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture. Preprints 2018, 2018110326. https://doi.org/10.20944/preprints201811.0326.v1

Abstract

Cellular agriculture is defined as the production of agricultural products from cell cultures rather than from whole plants or animals. With growing interest in cellular agriculture as a means to address the public health, environmental, and animal welfare challenges of animal agriculture, the concept of producing seafood from fish cell- and tissue-cultures is emerging as a means to address similar challenges with industrial aquaculture systems and marine capture. Cell-based seafood - as opposed to animal-based seafood - can combine developments in biomedical engineering with modern aquaculture techniques. Biomedical engineering developments such as closed-system bioreactor production of land animal cells create a basis for large scale production of marine animal cells. Aquaculture techniques such as genetic modification and closed system aquaculture have achieved marked gains in production that can pave the way for innovations in cell-based seafood production. Here, we present the current state of innovation relevant to the development of cell-based seafood across multiple species as well as specific opportunities and challenges that exist for advancing this science. The authors find that the physiological properties of fish cell- and tissue- culture may be uniquely suited to cultivation in vitro. These physiological properties, including hypoxia tolerance, high buffering capacity, and low-temperature growth conditions, make marine cell culture an attractive opportunity for scale production of cell-based seafood; perhaps even more so than mammalian and avian cell cultures for cell-based meats. This, coupled with the unique capabilities of crustacean tissue-friendly scaffolding such as chitosan, a common seafood waste product and mushroom derivative, presents great promise for cell-based seafood production via bioreactor cultivation. To become fully realized, cell-based seafood research will require more understanding of fish muscle culture and cultivation; more investigation into serum-free media formulations optimized for fish cell culture; and bioreactor designs tuned to the needs of fish cells for large scale production.

Keywords

cellular agriculture; cell-based seafood; fish tissue culture; bioreactor; serum-free media; ocean conservation; marine cell culture; aquaculture

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.