The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

Elias de França; Fábio Santos Lira; Marcio Flávio Ruaro; Vinicius Barroso Hirota; Paula A. Faria Waziry; André Rinaldi Fukushima; Maria Luiza de Jesus Miranda; Erico Chagas Caperuto

doi:10.20944/preprints201811.0189.v4

Preprint Review Version 4 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 5 November 2018 / Approved: 8 November 2018 / Online: 8 November 2018 (07:45:28 CET)
Version 2 : Received: 10 November 2018 / Approved: 12 November 2018 / Online: 12 November 2018 (06:48:00 CET)
Version 3 : Received: 28 November 2018 / Approved: 28 November 2018 / Online: 28 November 2018 (07:53:09 CET)
Version 4 : Received: 27 December 2018 / Approved: 28 December 2018 / Online: 28 December 2018 (04:39:00 CET)

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA or carnosine supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = −1.19, 95% CI −1.48 to −0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = − 0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: 0.06, 95% CI −0.38 to 0.500, p = 0.80). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS markers (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

beta-alanine; carnosine; oxidative stress; antioxidant

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The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

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