Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Freeform Perfusable Microfluidics Embedded in Hydrogel Matrices

Version 1 : Received: 2 November 2018 / Approved: 2 November 2018 / Online: 2 November 2018 (16:54:05 CET)

A peer-reviewed article of this Preprint also exists.

Štumberger, G.; Vihar, B. Freeform Perfusable Microfluidics Embedded in Hydrogel Matrices. Materials 2018, 11, 2529. Štumberger, G.; Vihar, B. Freeform Perfusable Microfluidics Embedded in Hydrogel Matrices. Materials 2018, 11, 2529.

Journal reference: Materials 2018, 11, 2529
DOI: 10.3390/ma11122529

Abstract

We report a modification of the freeform reversible embedding of suspended hydrogels (FRESH) 3D printing method for the fabrication of freeform perfusable microfluidics inside a hydrogel matrix. Xanthan gum is deposited into a CaCl2 infused gelatin slurry to form filaments, which are consequently rinsed to produce hollow channels. This provides a simple method for rapid prototyping of microfluidic devices based on biopolymers and potentially a new approach to the construction of vascular grafts for tissue engineering.

Keywords

Freeform, hydrogel, gelatin, microfluidics, FRESH, bioprinting, vascularization

Subject

LIFE SCIENCES, Other

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