Preprint Review Version 1 This version is not peer-reviewed

Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction

Version 1 : Received: 29 October 2018 / Approved: 31 October 2018 / Online: 31 October 2018 (04:51:16 CET)

A peer-reviewed article of this Preprint also exists.

Avecilla, V.; Avecilla, A. Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction. Med. Sci. 2019, 7, 7. Avecilla, V.; Avecilla, A. Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction. Med. Sci. 2019, 7, 7.

Journal reference: Med. Sci. 2019, 7, 7
DOI: 10.3390/medsci7010007

Abstract

The ongoing growth of international occurrence of depression and its ability to co-occur with other serious medical disorders such as heart disease, cancer, diabetes, and Parkinson’s disease is a current public health problem. Inhibitor of DNA-Binding/Differentiation (ID) proteins are part of a group of transcriptional factors that have been seen to be involved in neurocognitive disorders and therefore, may have influence on depressive disorders. Previously, it has been established that environmental estrogenic endocrine disruptors (EEDs) such as polychlorinated biphenyls (PCBs) & bisphenol A (BPA) have played an important role in the impact of depressive disorders. Hence, based on many studies, we consider the impact of these environmental pollutants on the group of ID proteins. Improved understanding of how the interaction of ID proteins by EED exposure can influence depressive disorders will contribute essential evidence that can further benefit our public health community with innovative knowledge to prevent these types of mental illnesses.

Subject Areas

depression; estrogenic endocrine disruptor; environmental factor; inhibitor of differentiation; mental disorder

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